Version 1
: Received: 16 September 2024 / Approved: 17 September 2024 / Online: 17 September 2024 (14:08:48 CEST)
How to cite:
Boi, L.; Menon, R.; Di Benedetto, B. Astrocyte Morphological Adaptations in a Mouse Model of Social Anxiety Disorder. Preprints2024, 2024091333. https://doi.org/10.20944/preprints202409.1333.v1
Boi, L.; Menon, R.; Di Benedetto, B. Astrocyte Morphological Adaptations in a Mouse Model of Social Anxiety Disorder. Preprints 2024, 2024091333. https://doi.org/10.20944/preprints202409.1333.v1
Boi, L.; Menon, R.; Di Benedetto, B. Astrocyte Morphological Adaptations in a Mouse Model of Social Anxiety Disorder. Preprints2024, 2024091333. https://doi.org/10.20944/preprints202409.1333.v1
APA Style
Boi, L., Menon, R., & Di Benedetto, B. (2024). Astrocyte Morphological Adaptations in a Mouse Model of Social Anxiety Disorder. Preprints. https://doi.org/10.20944/preprints202409.1333.v1
Chicago/Turabian Style
Boi, L., Rohit Menon and Barbara Di Benedetto. 2024 "Astrocyte Morphological Adaptations in a Mouse Model of Social Anxiety Disorder" Preprints. https://doi.org/10.20944/preprints202409.1333.v1
Abstract
The social fear conditioning (SFC) paradigm, which is an animal model of social anxiety disorder, has been extensively used to investigate the cellular and molecular mechanisms underlying the psychopathology of this disorder. Studies using the SFC paradigm have suggested that the lateral septum plays a pivotal role in regulating social fear. While several lines of evidence have indicated the involvement of various neuronal mechanisms within the LS in modulating social fear, the role played by LS astrocytes in the tripartite synapses in regulating social fear expression is not yet fully understood. Over the years, astrocytes have emerged as key players in regulating synaptic transmission and a plethora of animal behaviors. Given their dynamic morphological and molecular response to various stimuli, studying astrocyte morphology remains an excellent tool for understanding their role in brain function and disease. By applying immunofluorescent-immunohistochemical methods, here we describe a protocol to characterize changes in the morphology of astrocytes in response to social fear acquisition using confocal microscopy.
Keywords
Astrocytes, astrocyte morphology, social fear, lateral septum, mice
Subject
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
