Version 1
: Received: 18 September 2024 / Approved: 18 September 2024 / Online: 19 September 2024 (08:55:57 CEST)
How to cite:
Sarma, M. K.; Saucedo, A.; Sadananthan, S. A.; Darwin, C. H.; Felker, E. R.; Raman, S.; Velan, S. S.; Thomas, M. A. Lipid Deposition in Skeletal Muscle Tissues and Its Correlation with Intra-abdominal Fat: A Pilot Investigation in Type 2 Diabetes Mellitus. Preprints2024, 2024091386. https://doi.org/10.20944/preprints202409.1386.v1
Sarma, M. K.; Saucedo, A.; Sadananthan, S. A.; Darwin, C. H.; Felker, E. R.; Raman, S.; Velan, S. S.; Thomas, M. A. Lipid Deposition in Skeletal Muscle Tissues and Its Correlation with Intra-abdominal Fat: A Pilot Investigation in Type 2 Diabetes Mellitus. Preprints 2024, 2024091386. https://doi.org/10.20944/preprints202409.1386.v1
Sarma, M. K.; Saucedo, A.; Sadananthan, S. A.; Darwin, C. H.; Felker, E. R.; Raman, S.; Velan, S. S.; Thomas, M. A. Lipid Deposition in Skeletal Muscle Tissues and Its Correlation with Intra-abdominal Fat: A Pilot Investigation in Type 2 Diabetes Mellitus. Preprints2024, 2024091386. https://doi.org/10.20944/preprints202409.1386.v1
APA Style
Sarma, M. K., Saucedo, A., Sadananthan, S. A., Darwin, C. H., Felker, E. R., Raman, S., Velan, S. S., & Thomas, M. A. (2024). Lipid Deposition in Skeletal Muscle Tissues and Its Correlation with Intra-abdominal Fat: A Pilot Investigation in Type 2 Diabetes Mellitus. Preprints. https://doi.org/10.20944/preprints202409.1386.v1
Chicago/Turabian Style
Sarma, M. K., Sambasivam Sendhil Velan and Michael Albert Thomas. 2024 "Lipid Deposition in Skeletal Muscle Tissues and Its Correlation with Intra-abdominal Fat: A Pilot Investigation in Type 2 Diabetes Mellitus" Preprints. https://doi.org/10.20944/preprints202409.1386.v1
Abstract
This study evaluated metabolites and lipid composition in the calf muscles of Type 2 Diabetes Mellitus (T2DM) patients and age-matched healthy controls using multi-dimensional MR Spectroscopic Imaging. We also explored the association between muscle metabolites, lipids, and intra-abdominal fat in T2DM. Participants included 12 T2DM patients (60.3 ± 8.6 years), 9 age-matched healthy controls (AMHC) (60.9 ± 7.8 years), and 10 young healthy controls (YHC) (28.3 ± 1.8 years). We acquired 2D MR spectra of calf muscles using an enhanced accelerated 5D echo-planar correlated spectroscopic imaging (EP-COSI) technique, and abdominal MRI with breath-hold 6-point Dixon sequence. In YHC, choline levels were lower in the gastrocnemius (GAS) and soleus (SOL) muscles but higher in the tibialis anterior (TA) compared to AMHC. YHC also showed higher unsaturation index (U.I.) of extramyocellular lipids (EMCL) in TA, intramyocellular lipids (IMCL) in GAS, carnosine in SOL, and taurine and creatine in TA. T2DM patients exhibited higher choline in TA and myo-inositol in SOL than AMHC, while Triglyceride fats (TGFR2) in TA was lower. Correlation analysis indicated associations between IMCL U.I. and various metabolites in muscles with liver, pancreas, and abdominal fat estimates in T2DM. These findings may elucidate the impact of dysfunctional adipose tissues in T2DM.
Keywords
MR spectroscopic imaging; calf muscle lipids and metabolites; intra-abdominal fat; type 2 diabetes mellitus
Subject
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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