Version 1
: Received: 18 September 2024 / Approved: 18 September 2024 / Online: 19 September 2024 (12:13:00 CEST)
How to cite:
Sawai, K.; Goi, T.; Kimura, Y.; Koneri, K. Reduction of Blood Oxidative Stress Following Colorectal Cancer Resection. Preprints2024, 2024091455. https://doi.org/10.20944/preprints202409.1455.v1
Sawai, K.; Goi, T.; Kimura, Y.; Koneri, K. Reduction of Blood Oxidative Stress Following Colorectal Cancer Resection. Preprints 2024, 2024091455. https://doi.org/10.20944/preprints202409.1455.v1
Sawai, K.; Goi, T.; Kimura, Y.; Koneri, K. Reduction of Blood Oxidative Stress Following Colorectal Cancer Resection. Preprints2024, 2024091455. https://doi.org/10.20944/preprints202409.1455.v1
APA Style
Sawai, K., Goi, T., Kimura, Y., & Koneri, K. (2024). Reduction of Blood Oxidative Stress Following Colorectal Cancer Resection. Preprints. https://doi.org/10.20944/preprints202409.1455.v1
Chicago/Turabian Style
Sawai, K., Youhei Kimura and Kenji Koneri. 2024 "Reduction of Blood Oxidative Stress Following Colorectal Cancer Resection" Preprints. https://doi.org/10.20944/preprints202409.1455.v1
Abstract
Background: Colorectal cancer is a major global health burden, with surgical resection being the standard treatment aimed at curative tumor removal. Oxidative stress plays a crucial role in colorectal cancer progression and prognosis. This study hypothesized that physical removal of colorectal cancer, a primary source of oxidative stress, would reduce blood levels of reactive oxygen metabolite derivatives (d-ROMs), a marker of oxidative stress, and biologic antioxidant potential (BAP) levels, a marker of antioxidant potential. Methods: The study included 123 patients who underwent radical resection for colorectal cancer. d-ROM and BAP levels were measured before and one month after surgery. Results: The clinicopathological analysis showed a correlation between preoperative d-ROM levels and tumor size (p<0.001). The study confirmed a significant reduction in d-ROM levels following tumor resection, indicating reduced systemic oxidative stress. The reduction was significant in stages II and III but not in stage I. The d-ROM ratio before and after tumor resection was significantly higher in cases with positive lymph node metastasis and larger tumor size. BAP levels showed no significant changes post-surgery. Conclusion: These results suggest that d-ROMs could serve as a valuable biomarker for monitoring tumor burden and surgical efficacy in patients with colorectal cancer.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
