Possible Mechanisms and Strategies for Immune Therapy Resistance in Gastric Cancer

Xu Yuyu; Shen Huiling

doi:10.20944/preprints202409.1478.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 18 September 2024 / Approved: 19 September 2024 / Online: 19 September 2024 (11:49:59 CEST)
Version 2 : Received: 7 October 2024 / Approved: 8 October 2024 / Online: 8 October 2024 (13:44:17 CEST)

Gastric cancer has become one of the most common cancers in the world.Immunotherapy, especially immune point inhibitors targeting programmed cell death 1 or its ligand PD-L1, has been successfully applied in the clinical treatment of GC. However, only a small number of cancer patients experience persistent clinical responses during immunotherapy. In this review, we discussed the current status of immunotherapy for colorectal cancer, elucidated the mechanisms mediating immunotherapy resistance, predicted biomarkers for immunotherapy resistance, and strategies for improving immunotherapy efficacy.

gastric cancer; immunotherapy; Immune resistance; biomarker

Medicine and Pharmacology, Oncology and Oncogenics

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Possible Mechanisms and Strategies for Immune Therapy Resistance in Gastric Cancer

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