Unlocking the Therapeutic Potential of Oxystelma esculentum: A Phytochemical Treasure Trove with Anticancer and Lactogenic Properties

Maryem Safdar; Khalil Ahmad; Muhammad Younus Khan; Ghulam Sarwar; Muhammad Junaid Rao; Aqleem Abbas; Muhammad Taimoor Shakeel; Salma Batool; Abdulwahed Fahad Alrefaei; Mikhlid H. Almutairi

doi:10.20944/preprints202409.1609.v1

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preprints.org > biology and life sciences > biochemistry and molecular biology > doi: 10.20944/preprints202409.1609.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Unlocking the Therapeutic Potential of Oxystelma esculentum: A Phytochemical Treasure Trove with Anticancer and Lactogenic Properties

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Muhammad Taimoor Shakeel

Salma Batool

Abdulwahed Fahad Alrefaei

Mikhlid H. Almutairi

Version 1 : Received: 19 September 2024 / Approved: 20 September 2024 / Online: 20 September 2024 (09:43:46 CEST)

How to cite: Safdar, M.; Ahmad, K.; Khan, M. Y.; Sarwar, G.; Rao, M. J.; Abbas, A.; Shakeel, M. T.; Batool, S.; Alrefaei, A. F.; Almutairi, M. H. Unlocking the Therapeutic Potential of Oxystelma esculentum: A Phytochemical Treasure Trove with Anticancer and Lactogenic Properties. Preprints 2024, 2024091609. https://doi.org/10.20944/preprints202409.1609.v1 Safdar, M.; Ahmad, K.; Khan, M. Y.; Sarwar, G.; Rao, M. J.; Abbas, A.; Shakeel, M. T.; Batool, S.; Alrefaei, A. F.; Almutairi, M. H. Unlocking the Therapeutic Potential of Oxystelma esculentum: A Phytochemical Treasure Trove with Anticancer and Lactogenic Properties. Preprints 2024, 2024091609. https://doi.org/10.20944/preprints202409.1609.v1

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MDPI and ACS Style

Safdar, M.; Ahmad, K.; Khan, M. Y.; Sarwar, G.; Rao, M. J.; Abbas, A.; Shakeel, M. T.; Batool, S.; Alrefaei, A. F.; Almutairi, M. H. Unlocking the Therapeutic Potential of Oxystelma esculentum: A Phytochemical Treasure Trove with Anticancer and Lactogenic Properties. Preprints 2024, 2024091609. https://doi.org/10.20944/preprints202409.1609.v1

APA Style

Safdar, M., Ahmad, K., Khan, M. Y., Sarwar, G., Rao, M. J., Abbas, A., Shakeel, M. T., Batool, S., Alrefaei, A. F., & Almutairi, M. H. (2024). Unlocking the Therapeutic Potential of Oxystelma esculentum: A Phytochemical Treasure Trove with Anticancer and Lactogenic Properties. Preprints. https://doi.org/10.20944/preprints202409.1609.v1

Chicago/Turabian Style

Safdar, M., Abdulwahed Fahad Alrefaei and Mikhlid H. Almutairi. 2024 "Unlocking the Therapeutic Potential of Oxystelma esculentum: A Phytochemical Treasure Trove with Anticancer and Lactogenic Properties" Preprints. https://doi.org/10.20944/preprints202409.1609.v1

Abstract

This study investigates the phytochemical profile, cytotoxic effects, and lactogenic activity of Oxystelma esculentum, a plant renowned for its traditional medicinal uses. Preliminary phytochemical screening revealed a rich array of secondary metabolites, including alkaloids, flavonoids, glycosides, and tannins, predominantly in polar solvents such as methanol and ethanol. Spectroscopic analysis further identified key functional groups, suggesting significant bioactivity. The cytotoxic potential was evaluated against ovarian (OVCAR3), breast (T47D), and cervical (HeLa) cancer cell lines, demonstrating a concentration-dependent increase in cytotoxicity, with T47D cells exhibiting the highest sensitivity (IC50 = 42.82 μg/ml). Additionally, the brine shrimp lethality assay indicated low toxicity, while in vivo studies highlighted the extract's ability to enhance milk yield and pup growth in lactating rats, correlating with increased prolactin levels. These findings underscore Oxystelma esculentum as a promising candidate for natural anticancer therapies and lactation enhancement, warranting further exploration of its bioactive compounds and mechanisms of action.

Keywords

Phytochemical screening; Cytotoxicity; Anticancer activity; Lactogenic activity; Galactagogue; Prolactin; Brine shrimp lethality assay; FTIR spectroscopy; Medicinal plants; Natural products

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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