Version 1
: Received: 19 September 2024 / Approved: 20 September 2024 / Online: 20 September 2024 (11:32:11 CEST)
How to cite:
Di Cesare, A.; Rosi, E.; Scandagli, I.; Prignano, F. Comparison of Novel Hematological Biomarkers in Alopecia Areata and Other Not-Cicatricial Alopecia: A Retrospective Study. Preprints2024, 2024091619. https://doi.org/10.20944/preprints202409.1619.v1
Di Cesare, A.; Rosi, E.; Scandagli, I.; Prignano, F. Comparison of Novel Hematological Biomarkers in Alopecia Areata and Other Not-Cicatricial Alopecia: A Retrospective Study. Preprints 2024, 2024091619. https://doi.org/10.20944/preprints202409.1619.v1
Di Cesare, A.; Rosi, E.; Scandagli, I.; Prignano, F. Comparison of Novel Hematological Biomarkers in Alopecia Areata and Other Not-Cicatricial Alopecia: A Retrospective Study. Preprints2024, 2024091619. https://doi.org/10.20944/preprints202409.1619.v1
APA Style
Di Cesare, A., Rosi, E., Scandagli, I., & Prignano, F. (2024). Comparison of Novel Hematological Biomarkers in Alopecia Areata and Other Not-Cicatricial Alopecia: A Retrospective Study. Preprints. https://doi.org/10.20944/preprints202409.1619.v1
Chicago/Turabian Style
Di Cesare, A., Ilaria Scandagli and Francesca Prignano. 2024 "Comparison of Novel Hematological Biomarkers in Alopecia Areata and Other Not-Cicatricial Alopecia: A Retrospective Study" Preprints. https://doi.org/10.20944/preprints202409.1619.v1
Abstract
Introduction & Objectives: Blood cells-(BC)count derived parameters have been inves-tigated in systemic inflammation, cancer, and various cutaneous diseases. Little is known about their usefulness in trichology, especially as prognostic and therapeutic biomarkers. We conducted a retrospective study on patients with not-cicatricial alopecia to assess differences in BC-count. Materials & Methods: Patients with alopecia areata (AA), telogen effluvium (TE), androgenic alopecia (AGA), psoriasis and hidradenitis suppurativa (HS) were included in the study. Baseline complete BC-count and derived parameters (i.e. NLR, PLR, MLR, SII; PIV) were recorded and analyzed for each patient and at different timepoints for AA patients on systemic agents. Results: 170 patients fulfilled inclusion criteria. BC-count and derived values were similar across the not-cicatricial alopecia groups, while general differences were observed compared to psoriasis and HS. TE displayed a closer inflammatory signature to psoriasis with respect to CRP, NLR, MLR, SII and PIV. We also found a significant reduction in RBCs in severe versus patchy-AA and an increase of SII in acute versus chronic AA. Modulation of platelet number and volume could be used as therapeutic marker in AA. Conclusions: In our experience, the BC-count and its derived parameters could represent potential tools in AA and TE.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
