Version 1
: Received: 20 September 2024 / Approved: 20 September 2024 / Online: 23 September 2024 (11:53:36 CEST)
How to cite:
Wang, Q.; Yang, H.-S. The Impact of the Pdcd4, a Translation Inhibitor, on Drug Resistance. Preprints2024, 2024091669. https://doi.org/10.20944/preprints202409.1669.v1
Wang, Q.; Yang, H.-S. The Impact of the Pdcd4, a Translation Inhibitor, on Drug Resistance. Preprints 2024, 2024091669. https://doi.org/10.20944/preprints202409.1669.v1
Wang, Q.; Yang, H.-S. The Impact of the Pdcd4, a Translation Inhibitor, on Drug Resistance. Preprints2024, 2024091669. https://doi.org/10.20944/preprints202409.1669.v1
APA Style
Wang, Q., & Yang, H. S. (2024). The Impact of the Pdcd4, a Translation Inhibitor, on Drug Resistance. Preprints. https://doi.org/10.20944/preprints202409.1669.v1
Chicago/Turabian Style
Wang, Q. and Hsin-Sheng Yang. 2024 "The Impact of the Pdcd4, a Translation Inhibitor, on Drug Resistance" Preprints. https://doi.org/10.20944/preprints202409.1669.v1
Abstract
Programmed cell death 4 (Pdcd4) is a tumor suppressor, which has been demonstrated to efficiently suppress tumorigenesis. Biochemically, Pdcd4 binds with translation initiation factor 4A and represses protein translation. Beyond its role in tumor suppression, increasing evidence indicates that Pdcd4 enhances the chemosensitivity of several chemotherapeutic drugs. To date, several translational targets of Pdcd4 have been identified. These targets govern important signal transduction pathways, and their attenuation may enhance chemosensitivity or overcome drug resistance. This review will discuss the signal transduction pathways regulated by Pdcd4 and the potential mechanisms through which Pdcd4 enhances chemosensitivity or counteracts drug resistance.
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
