Longitudinal Fecal Microbiota Profiles in a Cohort of Non-Hospitalized Adolescents and Young Adults with COVID-19: Associations with SARS-CoV-2 Status and Long-Term Fatigue

Christine Olbjørn; Milada Hagen; Aina Fossum Moen; Lise Beier Havdal; Silke Lauren Sommen; Lise Lund Berven; Espen Thiis-Evensen; Tonje Stiansen-Sonerud; Joel Selvakumar; Vegard Bruun Bratholm Wyller

doi:10.20944/preprints202409.1824.v1

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preprints.org > medicine and pharmacology > pediatrics, perinatology and child health > doi: 10.20944/preprints202409.1824.v1

Preprint Article Version 1 This version is not peer-reviewed

Longitudinal Fecal Microbiota Profiles in a Cohort of Non-Hospitalized Adolescents and Young Adults with COVID-19: Associations with SARS-CoV-2 Status and Long-Term Fatigue

^* ,

Tonje Stiansen-Sonerud

Joel Selvakumar

Vegard Bruun Bratholm Wyller

Version 1 : Received: 23 September 2024 / Approved: 23 September 2024 / Online: 24 September 2024 (09:20:10 CEST)

How to cite: Olbjørn, C.; Hagen, M.; Fossum Moen, A.; Havdal, L. B.; Sommen, S. L.; Berven, L. L.; Thiis-Evensen, E.; Stiansen-Sonerud, T.; Selvakumar, J.; Bratholm Wyller, V. B. Longitudinal Fecal Microbiota Profiles in a Cohort of Non-Hospitalized Adolescents and Young Adults with COVID-19: Associations with SARS-CoV-2 Status and Long-Term Fatigue. Preprints 2024, 2024091824. https://doi.org/10.20944/preprints202409.1824.v1 Olbjørn, C.; Hagen, M.; Fossum Moen, A.; Havdal, L. B.; Sommen, S. L.; Berven, L. L.; Thiis-Evensen, E.; Stiansen-Sonerud, T.; Selvakumar, J.; Bratholm Wyller, V. B. Longitudinal Fecal Microbiota Profiles in a Cohort of Non-Hospitalized Adolescents and Young Adults with COVID-19: Associations with SARS-CoV-2 Status and Long-Term Fatigue. Preprints 2024, 2024091824. https://doi.org/10.20944/preprints202409.1824.v1

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MDPI and ACS Style

Olbjørn, C.; Hagen, M.; Fossum Moen, A.; Havdal, L. B.; Sommen, S. L.; Berven, L. L.; Thiis-Evensen, E.; Stiansen-Sonerud, T.; Selvakumar, J.; Bratholm Wyller, V. B. Longitudinal Fecal Microbiota Profiles in a Cohort of Non-Hospitalized Adolescents and Young Adults with COVID-19: Associations with SARS-CoV-2 Status and Long-Term Fatigue. Preprints 2024, 2024091824. https://doi.org/10.20944/preprints202409.1824.v1

APA Style

Olbjørn, C., Hagen, M., Fossum Moen, A., Havdal, L. B., Sommen, S. L., Berven, L. L., Thiis-Evensen, E., Stiansen-Sonerud, T., Selvakumar, J., & Bratholm Wyller, V. B. (2024). Longitudinal Fecal Microbiota Profiles in a Cohort of Non-Hospitalized Adolescents and Young Adults with COVID-19: Associations with SARS-CoV-2 Status and Long-Term Fatigue. Preprints. https://doi.org/10.20944/preprints202409.1824.v1

Chicago/Turabian Style

Olbjørn, C., Joel Selvakumar and Vegard Bruun Bratholm Wyller. 2024 "Longitudinal Fecal Microbiota Profiles in a Cohort of Non-Hospitalized Adolescents and Young Adults with COVID-19: Associations with SARS-CoV-2 Status and Long-Term Fatigue" Preprints. https://doi.org/10.20944/preprints202409.1824.v1

Abstract

Adolescents most often experience mild acute COVID-19 but may still face fatigue and persistent symptoms such as post-COVID-19 condition (PCC) and post-infective fatigue syndrome (PIFS). We explored the fecal microbiota in a prospective controlled cohort of 136 non-hospitalized SARS-CoV-2-positive and 32 SARS-CoV-2-negative controls aged 12–25 years. With a targeted qPCR approach, the quantities of 100 fecal bacterial taxa were measured at baseline (early convalescent stage) and after six months. Results: Faecalibacterium prausnitzii M21.2 and Gemmiger formicilis (both p<0.001) were enriched in the SARS-CoV-2-positive participants compared to controls at baseline. Lower baseline abundance of Faecalibacterium prausnitzii M21/2 (p=0.013) and higher abundance of Clostridium spiroforme (p=0.006), Sutterella wadsworthensis (p<0.001) and Streptococcus thermophilus (p=0.039) were associated with six-month fatigue. Sutterella wadsworthensis and Streptococcus thermophilus enrichment was additionally associated with PCC in the SARS-CoV-2-positive group (p<0.001 and 0.042 respectively). Conclusions: In mild SARS-CoV-2 infection in adolescents and young adults, beneficial Faecalibacterium prausnitzii M21/2 and Gemmiger formicilis were enriched compared to SARS-CoV-2 negative controls. Additionally, both known (Faecalibacterium prausnitzii, Streptococcus thermophilus) and new (Clostridium spiroforme, Sutterella wadsworthensis) bacteria were associated with persistent symptoms in the COVID-19 infected group, warranting further exploration of the role of these bacteria in COVID-19 disease and PCC pathophysiology.

Keywords

SARS-CoV-2; COVID-19; fatigue; post-COVID-19 condition; post-infective fatigue syndrome; microbiota; Faecalibacterium prausnitzii; Sutterella wadsworthensis

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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