Preprint Article Version 1 This version is not peer-reviewed

Correlation Between IgA Levels in Henoch–Schönlein Purpura and a Medical History of Infectious Disease in the Pediatric Population: A Five-Year Retrospective Analysis

Sînziana Oprițescu
ORCID logo ,
Gabriela Viorela Nițescu
* ,
Mihaela Golumbeanu
,
Dora Boghițoiu
,
Elena Iuliana Ioniță
,
Diana-Andreea Ușurelu
,
Cristian Lucaci
,
Adriana Negoiță
,
Elena Moroșan
Version 1 : Received: 23 September 2024 / Approved: 24 September 2024 / Online: 24 September 2024 (11:57:35 CEST)

How to cite: Oprițescu, S.; Nițescu, G. V.; Golumbeanu, M.; Boghițoiu, D.; Ioniță, E. I.; Ușurelu, D.-A.; Lucaci, C.; Negoiță, A.; Moroșan, E. Correlation Between IgA Levels in Henoch–Schönlein Purpura and a Medical History of Infectious Disease in the Pediatric Population: A Five-Year Retrospective Analysis. Preprints 2024, 2024091873. https://doi.org/10.20944/preprints202409.1873.v1 Oprițescu, S.; Nițescu, G. V.; Golumbeanu, M.; Boghițoiu, D.; Ioniță, E. I.; Ușurelu, D.-A.; Lucaci, C.; Negoiță, A.; Moroșan, E. Correlation Between IgA Levels in Henoch–Schönlein Purpura and a Medical History of Infectious Disease in the Pediatric Population: A Five-Year Retrospective Analysis. Preprints 2024, 2024091873. https://doi.org/10.20944/preprints202409.1873.v1

Abstract

Immunoglobulin A (IgA) vasculitis (IgAV), classically known as Henoch–Schönlein purpura (HSP), is a type of non-thrombocytopenic small-vessel vasculitis. HSP is the most frequent kind of systemic vasculitis in children, characterized by purpura, arthritis or arthralgia, gastrointestinal pain, and kidney dysfunction. The aim of our research was to investigate and observe the clinical characteristics of children diagnosed with HSP and to explore the correlation between infectious diseases and HSP. Furthermore, this retrospective study considered other factors, such as demographic characteristics (sex, area/environment, and age), and their effect on the pediatric population diagnosed with HSP. To answer this question, we conducted a five-year hospital-based retrospective study that included 144 hospitalized children who were diagnosed with HSP during hospitalization. Measurements of immunological panels (IgA, IgM, IgG, and IgE), C3, C4, C-reactive protein, fibrinogen, and hematite sedimentation rate (VSH) determined using blood samples revealed that there is a strong correlation between the elements of the immunological panel and the HSP manifestations. Moreover, elevated IgG and IgM levels in pediatric HSP patients are strongly linked to infectious diseases. Notably, patients who tested positive for pathogens in their IgG- or IgM-specific blood tests also had high IgG or IgM serum levels.

Keywords

Henoch–Schönlein purpura; IgA vasculitis; allergic vasculitis; infectious diseases

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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