Version 1
: Received: 24 September 2024 / Approved: 24 September 2024 / Online: 25 September 2024 (11:39:40 CEST)
How to cite:
Hebchen, D. M.; Schröder, K. Redox Signaling in Endosomes on the Example of EGF Receptors. Preprints2024, 2024091937. https://doi.org/10.20944/preprints202409.1937.v1
Hebchen, D. M.; Schröder, K. Redox Signaling in Endosomes on the Example of EGF Receptors. Preprints 2024, 2024091937. https://doi.org/10.20944/preprints202409.1937.v1
Hebchen, D. M.; Schröder, K. Redox Signaling in Endosomes on the Example of EGF Receptors. Preprints2024, 2024091937. https://doi.org/10.20944/preprints202409.1937.v1
APA Style
Hebchen, D. M., & Schröder, K. (2024). Redox Signaling in Endosomes on the Example of EGF Receptors. Preprints. https://doi.org/10.20944/preprints202409.1937.v1
Chicago/Turabian Style
Hebchen, D. M. and Katrin Schröder. 2024 "Redox Signaling in Endosomes on the Example of EGF Receptors" Preprints. https://doi.org/10.20944/preprints202409.1937.v1
Abstract
Early Endosomes represent first line sorting compartments or even organelles for internalized molecules. They enable the transport of molecules or ligands to other compartments of the cell, such as lysosomes for degradation or recycle them back to the membrane by various mechanisms. Moreover, early endosomes function as signaling and scaffolding platform to initiate or prolong distinct signaling pathways. Accordingly, early endosomes have to be recognized as either part of a degradation or recycling pathway. The physical proximity of many ligand-binding receptors with other membrane bound proteins or complexes such as NADPH oxidases may result in an interaction of second messengers like reactive oxygen species (ROS) and early endosomes that promote correct recognition of individual early endosomes. In fact, redoxosomes comprise an endosomal subsection of signaling endosomes. One example of such potential interaction is epidermal growth factor receptor (EGFR) signaling. Here we summarize recent findings on EGFR signaling as a well-studied example for receptor trafficking and trans-activation and illustrating the interplay between cellular and endosomal ROS.
Keywords
early endosomes; redoxosomes; trans-activation; EGFR; reactive oxygen species
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
