Version 1
: Received: 24 September 2024 / Approved: 24 September 2024 / Online: 24 September 2024 (14:52:39 CEST)
How to cite:
Kwon, K. J.; Kim, H. Y.; Han, S.-H.; Shin, C. Y. Future Therapeutic Strategies for Alzheimer’s Disease: Focus on Behavioral and Psychological Symptoms. Preprints2024, 2024091944. https://doi.org/10.20944/preprints202409.1944.v1
Kwon, K. J.; Kim, H. Y.; Han, S.-H.; Shin, C. Y. Future Therapeutic Strategies for Alzheimer’s Disease: Focus on Behavioral and Psychological Symptoms. Preprints 2024, 2024091944. https://doi.org/10.20944/preprints202409.1944.v1
Kwon, K. J.; Kim, H. Y.; Han, S.-H.; Shin, C. Y. Future Therapeutic Strategies for Alzheimer’s Disease: Focus on Behavioral and Psychological Symptoms. Preprints2024, 2024091944. https://doi.org/10.20944/preprints202409.1944.v1
APA Style
Kwon, K. J., Kim, H. Y., Han, S. H., & Shin, C. Y. (2024). Future Therapeutic Strategies for Alzheimer’s Disease: Focus on Behavioral and Psychological Symptoms. Preprints. https://doi.org/10.20944/preprints202409.1944.v1
Chicago/Turabian Style
Kwon, K. J., Seol-Heui Han and Chan Young Shin. 2024 "Future Therapeutic Strategies for Alzheimer’s Disease: Focus on Behavioral and Psychological Symptoms" Preprints. https://doi.org/10.20944/preprints202409.1944.v1
Abstract
Alzheimer’s disease (AD) is a progressive, degenerative brain disorder that impairs memory and thinking skills, leading to significant economic and humanistic burdens. It is associated with various neuropsychiatric symptoms (NPSs) such as anxiety, agitation, depression, aggression, apathy, and psychosis. NPSs are common in patients with AD, affecting up to 97% of individuals diagnosed with AD. The severity of NPS is linked to disease progression and cognitive decline. NPS in Alzheimer’s disease leads to increased morbidity, mortality, caregiver burden, earlier nursing home placement, and higher healthcare costs. Despite their significant impact, clinical research on NPS in AD is limited. In clinical settings, accurately distinguishing and diagnosing NPS related to AD remains a challenge. Additionally, conventional treatments for NPS in AD are often ineffective, highlighting the need for new therapies that target these specific symptoms. Understanding these comorbidities can aid in early diagnosis and better management of AD.
In this review, we provide a summary of the various neurological and psychiatric symptoms (NPSs) associated with AD and new candidates under development for the treatment of NPSs based on their therapeutic targets and mechanisms. On top of the conventional NPSs studied far, this review adds recent advancements in the understanding of social functional impairment in AD. This review also provides information that can contribute to the advancement of studies and translational research in this field by emphasizing therapeutic targets and mechanism of action focused on AD-related NPS, rather than conventional mechanisms targeted in AD drug development. Above all, considering the relative lack of research in this new field despite the importance of clinical, medical, and translational research, it may increase interest in NPSs in AD, its pathophysiological mechanisms, and potential therapeutic candidates such as molecules with antioxidant potential.
Keywords
Alzheimer's disease; Neuropsychiatric symptoms; Psychomotor symptoms; Social function; Pharmacotherapy
Subject
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
