Version 1
: Received: 24 September 2024 / Approved: 25 September 2024 / Online: 25 September 2024 (09:00:52 CEST)
How to cite:
Aguilar-Garcia, I. G.; Alpirez, J.; Castañeda-Arellano, R.; Dueñas-Jiménez, J. M.; Toro-Castillo, M. D. C.; León-Moreno, L. C.; Osuna-Carrasco, L. P.; Dueñas-Jiménez, S. H. Resveratrol and Exercise Produce a Recovery Ankle and Metatarsus Joint Movements After a Penetrating Lesion in the Hippocampus in Male Rats. Preprints2024, 2024091965. https://doi.org/10.20944/preprints202409.1965.v1
Aguilar-Garcia, I. G.; Alpirez, J.; Castañeda-Arellano, R.; Dueñas-Jiménez, J. M.; Toro-Castillo, M. D. C.; León-Moreno, L. C.; Osuna-Carrasco, L. P.; Dueñas-Jiménez, S. H. Resveratrol and Exercise Produce a Recovery Ankle and Metatarsus Joint Movements After a Penetrating Lesion in the Hippocampus in Male Rats. Preprints 2024, 2024091965. https://doi.org/10.20944/preprints202409.1965.v1
Aguilar-Garcia, I. G.; Alpirez, J.; Castañeda-Arellano, R.; Dueñas-Jiménez, J. M.; Toro-Castillo, M. D. C.; León-Moreno, L. C.; Osuna-Carrasco, L. P.; Dueñas-Jiménez, S. H. Resveratrol and Exercise Produce a Recovery Ankle and Metatarsus Joint Movements After a Penetrating Lesion in the Hippocampus in Male Rats. Preprints2024, 2024091965. https://doi.org/10.20944/preprints202409.1965.v1
APA Style
Aguilar-Garcia, I. G., Alpirez, J., Castañeda-Arellano, R., Dueñas-Jiménez, J. M., Toro-Castillo, M. D. C., León-Moreno, L. C., Osuna-Carrasco, L. P., & Dueñas-Jiménez, S. H. (2024). Resveratrol and Exercise Produce a Recovery Ankle and Metatarsus Joint Movements After a Penetrating Lesion in the Hippocampus in Male Rats. Preprints. https://doi.org/10.20944/preprints202409.1965.v1
Chicago/Turabian Style
Aguilar-Garcia, I. G., Laura Paulina Osuna-Carrasco and Sergio Horacio Dueñas-Jiménez. 2024 "Resveratrol and Exercise Produce a Recovery Ankle and Metatarsus Joint Movements After a Penetrating Lesion in the Hippocampus in Male Rats" Preprints. https://doi.org/10.20944/preprints202409.1965.v1
Abstract
This study investigates how traumatic injuries alter joint movements in the ankle and foot. We used a brain injury model in rats, focusing on the hippocampus between the CA1 and dentate gyrus. We assessed the dissimilarity factor (DF) and vertical displacement (VD) of the ankle and metatarsus joints before and after the hippocampal lesion. We analyzed joint movements in rats after the injury or in rats treated with resveratrol, exercise, or a combination of both. Resveratrol facilitated the recovery of DF in both legs, showing improvements in the ankle and metatarsus joints on the third- and seventh days post-injury. The hippocampal lesion affected VD in both legs, observed on the third or seventh day after the injury. Both exercise and resveratrol partially recovered VD in the ankle and metatarsus joints on these days. These effects may be linked to increased hippocampal neurogenesis and reduced neuroinflammation. The study highlights the benefits of resveratrol and exercise in motor recovery following brain injury, suggesting their potential to enhance the quality of life for patients with neurological disorders affecting motor function and locomotion. These findings also suggest that resveratrol could offer a promising or complementary alternative in managing chronic pain and inflammation associated with orthopedic conditions, thus improving overall patient management.
Keywords
Locomotion; Kinematics; Resveratrol; exercise
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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