Preprint Article Version 1 This version is not peer-reviewed

Development of an Eco-Friendly Nanogel Incorporating Pectis brevipedunculata Essential Oil as Larvicidal Agent Against Aedes aegypti

Estela Mesquita Marques
,
Raiene Lisboa Rocha
,
Clenilma Marques Brandão
ORCID logo ,
Júlia Karla de Albuquerque Melo Xavier
,
Marcos Bispo Pinheiro Camara
,
Caritas de Jesus Silva Mendonça
,
Roberto Batista de Lima
,
Melissa Pires Souza
,
Emmanoel Vilaça Costa
ORCID logo ,
Renato Sonchini Gonçalves
*
Version 1 : Received: 24 September 2024 / Approved: 25 September 2024 / Online: 25 September 2024 (12:10:31 CEST)

How to cite: Marques, E. M.; Rocha, R. L.; Brandão, C. M.; Xavier, J. K. D. A. M.; Camara, M. B. P.; Mendonça, C. D. J. S.; de Lima, R. B.; Souza, M. P.; Costa, E. V.; Gonçalves, R. S. Development of an Eco-Friendly Nanogel Incorporating Pectis brevipedunculata Essential Oil as Larvicidal Agent Against Aedes aegypti. Preprints 2024, 2024092001. https://doi.org/10.20944/preprints202409.2001.v1 Marques, E. M.; Rocha, R. L.; Brandão, C. M.; Xavier, J. K. D. A. M.; Camara, M. B. P.; Mendonça, C. D. J. S.; de Lima, R. B.; Souza, M. P.; Costa, E. V.; Gonçalves, R. S. Development of an Eco-Friendly Nanogel Incorporating Pectis brevipedunculata Essential Oil as Larvicidal Agent Against Aedes aegypti. Preprints 2024, 2024092001. https://doi.org/10.20944/preprints202409.2001.v1

Abstract

Arboviruses, transmitted by mosquitoes like Aedes aegypti, pose significant public health challenges globally, particularly in tropical regions. The rapid spread and adaptation of viruses such as Dengue, Zika, and Chikungunya have emphasized the need for innovative control methods. Larvicide property of essential oils has emerged as a potential alternative to conventional insecticides. This work showed the development of an eco-friendly nanogel using a low-energy, solvent-free method, incorporating the copolymer F127 and carbopol 974p with a high concentration of essential oil from Pectis brevipedunculata (Gardner) Sch.Bip. (Pb). The resulting nanogel displayed excellent physical stability and was maintained under varying temperature conditions. Characterization techniques, including FTIR and DLS, confirmed the stable incorporation of essential oil (EOPb) within the nanogel matrix. The in vitro assays against Aedes aegypti larvae revealed that at 500 μg/mL, the mortality rates was 96.0% ± 7.0 after 24 h and 100.0% ± 0.0 after 48 h. The positive control group treated with temephos, achieved 100% mortality at both time points, validating the experimental conditions and providing a benchmark for assessing the efficacy of the nGF2002Pb nanogel. These results indicate that the nGF2002Pb demonstrates a pronounced concentration-dependent larvicidal effect against Aedes aegypti, offering an innovative and sustainable approach for arbovirus vector control.

Keywords

thermoresponsive nanogel; Pectis brevipendunculata essencial oil; Aedes aegypti

Subject

Chemistry and Materials Science, Nanotechnology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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