Version 1
: Received: 25 September 2024 / Approved: 25 September 2024 / Online: 25 September 2024 (17:07:36 CEST)
How to cite:
Vakili, S.; Barzegar Behrooz, A.; Wichelo, R.; Fernades, A.; Emwas, A.-H.; Jaremko, M.; Markowski, J.; Łos, M. J.; Ghavami, S.; Vitorino, R. Progress in Precision Medicine for Head and Neck Cancer. Preprints2024, 2024092042. https://doi.org/10.20944/preprints202409.2042.v1
Vakili, S.; Barzegar Behrooz, A.; Wichelo, R.; Fernades, A.; Emwas, A.-H.; Jaremko, M.; Markowski, J.; Łos, M. J.; Ghavami, S.; Vitorino, R. Progress in Precision Medicine for Head and Neck Cancer. Preprints 2024, 2024092042. https://doi.org/10.20944/preprints202409.2042.v1
Vakili, S.; Barzegar Behrooz, A.; Wichelo, R.; Fernades, A.; Emwas, A.-H.; Jaremko, M.; Markowski, J.; Łos, M. J.; Ghavami, S.; Vitorino, R. Progress in Precision Medicine for Head and Neck Cancer. Preprints2024, 2024092042. https://doi.org/10.20944/preprints202409.2042.v1
APA Style
Vakili, S., Barzegar Behrooz, A., Wichelo, R., Fernades, A., Emwas, A. H., Jaremko, M., Markowski, J., Łos, M. J., Ghavami, S., & Vitorino, R. (2024). Progress in Precision Medicine for Head and Neck Cancer. Preprints. https://doi.org/10.20944/preprints202409.2042.v1
Chicago/Turabian Style
Vakili, S., Saeid Ghavami and Rui Vitorino. 2024 "Progress in Precision Medicine for Head and Neck Cancer" Preprints. https://doi.org/10.20944/preprints202409.2042.v1
Abstract
This paper presents a comprehensive comparative analysis of head and neck cancer (HNC) biomarkers, a prevalent but molecularly diverse malignancy. We detail the roles of key proteins and genes in tumorigenesis and progression, emphasizing their diagnostic, prognostic, and therapeutic relevance. Our bioinformatic validation reveals crucial genes such as AURKA, HMGA2, MMP1, PLAU, and SERPINE1, along with microRNAs (miRNA) linked to HNC progression. OncomiRs, including hsa-miR-21-5p, hsa-miR-31-5p, hsa-miR-221-3p, hsa-miR-222-3p, hsa-miR-196a-5p, and hsa-miR-200c-3p, drive tumorigenesis, while tumour-suppressive miRNAs like hsa-miR-375 and hsa-miR-145-5p inhibit it. Notably, hsa-miR-155-3p correlates with survival outcomes in addition to genes RAI14, S1PR5, OSBPL10, and METTL6, highlighting its prognostic potential. Future directions focus on leveraging precision medicine, novel therapeutics, and AI integration to advance personalized treatment strategies to optimize patient outcomes in HNC care.
Keywords
Precision Medicine; Biomarkers; Genetic Alterations; Head and Neck Cancer; Targeted Therapy
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.