Neurotensin and Its Involvement in Female Hormone-Sensitive Cancers

Ninon Bertrand; Romane Mougel; George Riley; Marie Bruand; Guillaume GAUCHOTTE; Mikaël Agopiantz

doi:10.20944/preprints202409.2086.v1

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preprints.org > medicine and pharmacology > oncology and oncogenics > doi: 10.20944/preprints202409.2086.v1

Preprint Review Version 1 This version is not peer-reviewed

Neurotensin and Its Involvement in Female Hormone-Sensitive Cancers

Version 1 : Received: 25 September 2024 / Approved: 26 September 2024 / Online: 26 September 2024 (11:33:49 CEST)

How to cite: Bertrand, N.; Mougel, R.; Riley, G.; Bruand, M.; GAUCHOTTE, G.; Agopiantz, M. Neurotensin and Its Involvement in Female Hormone-Sensitive Cancers. Preprints 2024, 2024092086. https://doi.org/10.20944/preprints202409.2086.v1 Bertrand, N.; Mougel, R.; Riley, G.; Bruand, M.; GAUCHOTTE, G.; Agopiantz, M. Neurotensin and Its Involvement in Female Hormone-Sensitive Cancers. Preprints 2024, 2024092086. https://doi.org/10.20944/preprints202409.2086.v1

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MDPI and ACS Style

Bertrand, N.; Mougel, R.; Riley, G.; Bruand, M.; GAUCHOTTE, G.; Agopiantz, M. Neurotensin and Its Involvement in Female Hormone-Sensitive Cancers. Preprints 2024, 2024092086. https://doi.org/10.20944/preprints202409.2086.v1

APA Style

Bertrand, N., Mougel, R., Riley, G., Bruand, M., GAUCHOTTE, G., & Agopiantz, M. (2024). Neurotensin and Its Involvement in Female Hormone-Sensitive Cancers. Preprints. https://doi.org/10.20944/preprints202409.2086.v1

Chicago/Turabian Style

Bertrand, N., Guillaume GAUCHOTTE and Mikaël Agopiantz. 2024 "Neurotensin and Its Involvement in Female Hormone-Sensitive Cancers" Preprints. https://doi.org/10.20944/preprints202409.2086.v1

Abstract

Neurotensin (NT) is a peptide involved in digestion, neuromodulation, and cancer progression. NT and its receptors (NTR1 and SORT1 mainly) have been widely studied in oncology. Data show NT expression is under the control of sex steroid hormones, in particular estradiol. We focused on its involvement in three main female hormone-sensitive cancers: breast, ovarian, and endometrial cancer in a narrative review. NT, NTR1 and SORT1 are mostly expressed in these three cancers and their involvement in oncologic processes such as proliferation and invasion seems to match, as does their impact on prognosis for most. The development of NT receptor-targeted therapies, including theranostics and radioligand treatments, presents a promising avenue for personalized cancer treatment.

Keywords

neurotensin; breast cancer; ovarian cancer; endometrial cancer

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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