Preprint Article Version 1 This version is not peer-reviewed

Exploring the Impact of IL-33 Gene Polymorphism (rs1929992) on Susceptibility to Chronic Urticaria and its Association with Serum Interleukin-33 levels

Carmen-Teodora Dobrican-Băruța
ORCID logo ,
Diana Mihaela Deleanu
,
Mihaela Iancu
* ORCID logo ,
Ioana Adriana Muntean
ORCID logo ,
Irena Nedelea
,
Radu-Gheorghe Bălan
,
Lucia Maria Procopciuc
,
Gabriela Adriana Filip
Version 1 : Received: 25 September 2024 / Approved: 25 September 2024 / Online: 26 September 2024 (17:07:22 CEST)

How to cite: Dobrican-Băruța, C.-T.; Deleanu, D. M.; Iancu, M.; Muntean, I. A.; Nedelea, I.; Bălan, R.-G.; Procopciuc, L. M.; Filip, G. A. Exploring the Impact of IL-33 Gene Polymorphism (rs1929992) on Susceptibility to Chronic Urticaria and its Association with Serum Interleukin-33 levels. Preprints 2024, 2024092089. https://doi.org/10.20944/preprints202409.2089.v1 Dobrican-Băruța, C.-T.; Deleanu, D. M.; Iancu, M.; Muntean, I. A.; Nedelea, I.; Bălan, R.-G.; Procopciuc, L. M.; Filip, G. A. Exploring the Impact of IL-33 Gene Polymorphism (rs1929992) on Susceptibility to Chronic Urticaria and its Association with Serum Interleukin-33 levels. Preprints 2024, 2024092089. https://doi.org/10.20944/preprints202409.2089.v1

Abstract

Chronic urticaria (CU) is a debilitating skin condition affecting up to 20% of the global popula-tion, characterized by erythematous, maculo-papular lesions and significant quality of life im-pairment. This study focused on the role of interleukin 33 (IL-33) and its polymorphisms, partic-ularly SNP rs1929992, in chronic spontaneous urticaria (CSU). Using demographic, clinical, and laboratory data from CU patients and controls, we aestimated allele and genotype frequencies, Hardy-Weinberg equilibrium condition, and serum IL-33 levels, using unconditional binomial logistic regression for association analysis. Results revealed that CU patients had significantly higher frequencies of the minor allele of IL33 rs1929992 compared to controls (31.25% vs. 17.35%, p = 0.024), and carriers of the AG genotype exhibited increased odds of CU (adjusted OR = 2.208, p ≤ 0.001). Additionally, serum IL-33 levels were markedly elevated in CU patients, par-ticularly those with the GA genotype. The findings suggest that the IL-33 SNP rs1929992 is asso-ciated with an increased susceptibility to CSU, emphasizing its potential as a diagnostic and therapeutic biomarker. This study underscores the genetic and immunological underpinnings of CSU, paving the way for personalized treatment approaches.

Keywords

chronic urticaria; genetic polymorphisms; IL-33; SNP rs1929992; cytokine; autoimmune; susceptibility

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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