Version 1
: Received: 25 September 2024 / Approved: 25 September 2024 / Online: 26 September 2024 (17:08:49 CEST)
How to cite:
Bellia, C.; Sardina, D. S.; Scazzone, C.; Lio, D.; Scola, L.; Uasuf, C. G. Diagnostic Accuracy of Specific IgE to Lipid Transfer Proteins (LTPs) in Food Allergy: A Systematic Review. Preprints2024, 2024092091. https://doi.org/10.20944/preprints202409.2091.v1
Bellia, C.; Sardina, D. S.; Scazzone, C.; Lio, D.; Scola, L.; Uasuf, C. G. Diagnostic Accuracy of Specific IgE to Lipid Transfer Proteins (LTPs) in Food Allergy: A Systematic Review. Preprints 2024, 2024092091. https://doi.org/10.20944/preprints202409.2091.v1
Bellia, C.; Sardina, D. S.; Scazzone, C.; Lio, D.; Scola, L.; Uasuf, C. G. Diagnostic Accuracy of Specific IgE to Lipid Transfer Proteins (LTPs) in Food Allergy: A Systematic Review. Preprints2024, 2024092091. https://doi.org/10.20944/preprints202409.2091.v1
APA Style
Bellia, C., Sardina, D. S., Scazzone, C., Lio, D., Scola, L., & Uasuf, C. G. (2024). Diagnostic Accuracy of Specific IgE to Lipid Transfer Proteins (LTPs) in Food Allergy: A Systematic Review. Preprints. https://doi.org/10.20944/preprints202409.2091.v1
Chicago/Turabian Style
Bellia, C., Letizia Scola and Carina Gabriela Uasuf. 2024 "Diagnostic Accuracy of Specific IgE to Lipid Transfer Proteins (LTPs) in Food Allergy: A Systematic Review" Preprints. https://doi.org/10.20944/preprints202409.2091.v1
Abstract
Background: The aim of this systematic review was to evaluate diagnostic accuracy of
molecular-based LTPs serum IgE for the diagnosis of food allergies in patients with suspected
allergy to one of the LTPs-containing food. Methods: cohort, prospective or retrospective cross-
sectional studies were considered for inclusion in the review. Oral food challenge (both open and
double-blind placebo-controlled) was the reference standard for the diagnosis. Pubmed
(MEDLINE), Web of Science, Scopus, and ClinicalTrial.org were searched for relevant papers.
Risk of bias was assigned by QUADAS-2 tool. Data were reported as sensitivity and specificity.
Study protocol was registered in the PROSPERO database (CRD42022321985). Results: Fifteen
articles, including 2395 individuals, were included. Sensitivity of Ara h 9 for peanut allergy
diagnosis ranged from 6 to 61%; specificity ranged from 57 to 100%. Cor a 8 sensitivity ranged
from 11 to 43%, with specificity ranging from 59 to 94%. Conclusions: Ara h9 and Cor a 8 serum
IgE may be useful to confirm diagnosis of peanut and hazelnut allergy in symptomatic patients,
although diagnostic accuracy is limited by low sensitivity. More investigation on other LTPs and in
adult population may be important to define the clinical role of this test in food allergies
diagnostics.
Keywords
food hypersensitivity; lipid transfer protein; IgE; component resolved diagnosis
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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