Tita, A.; Isac, S.; Isac, T.; Martac, C.; Geani-Danut, T.; Jipa, L.; Cobilinschi, C.; Pavel, B.; Tanasescu, M.-D.; Mirea, L. E.; Droc, G. A Multivariate Phenotypical Approach of Sepsis and Septic Shock – a Comprehensive Narrative Literature Review. Preprints2024, 2024092197. https://doi.org/10.20944/preprints202409.2197.v1
APA Style
Tita, A., Isac, S., Isac, T., Martac, C., Geani-Danut, T., Jipa, L., Cobilinschi, C., Pavel, B., Tanasescu, M. D., Mirea, L. E., & Droc, G. (2024). A Multivariate Phenotypical Approach of Sepsis and Septic Shock – a Comprehensive Narrative Literature Review. Preprints. https://doi.org/10.20944/preprints202409.2197.v1
Chicago/Turabian Style
Tita, A., Liliana Elena Mirea and Gabriela Droc. 2024 "A Multivariate Phenotypical Approach of Sepsis and Septic Shock – a Comprehensive Narrative Literature Review" Preprints. https://doi.org/10.20944/preprints202409.2197.v1
Abstract
Despite medical advances, sepsis and septic shock remain one of the leading causes of mortality worldwide, with a high inter-individual variability in prognosis, clinical manifestations and response to treatment. Given the heterogeneity of sepsis and recent technological progress amongst machine learning analysis technique, a new, personalized approach in sepsis is being intensively studied. Despite the difficulties when tailoring a targeted approach, with the use of artificial intelligence-based pattern recognition, more and more publications are becoming available, highlighting novel factors that may intervene in the high heterogenicity of sepsis. This has led to the devise of a phenotypical approach in sepsis, further dividing patients based on host and trigger-related factors, clinical manifestations and progression towards organ deficiencies, dynamic prognosis algorithms and patient trajectory in the Intensive Care Unit (ICU). Host and trigger-related factors refer to patients’ comorbidities, body-mass index, age, temperature, immune response, type of bacteria and infection site. The progression to organ deficiencies refers to individual particularities of sepsis-related multiorgan failure. Finally, the patient’s trajectory in the ICU points out the need of a better understanding of interindividual response to various supportive therapies. This review aims to identify the main sources of variability in clustering septic patients in various clinical phenotypes, as a useful clinical tool for precision-based approach in sepsis and septic shock.
Medicine and Pharmacology, Anesthesiology and Pain Medicine
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