Version 1
: Received: 30 September 2024 / Approved: 30 September 2024 / Online: 30 September 2024 (18:24:17 CEST)
How to cite:
García, A. H.; De Sanctis, J. B. Exploring the Contrasts and Similarities of Dengue and SARS-CoV-2 Infections during the COVID-19 Era. Preprints2024, 2024092464. https://doi.org/10.20944/preprints202409.2464.v1
García, A. H.; De Sanctis, J. B. Exploring the Contrasts and Similarities of Dengue and SARS-CoV-2 Infections during the COVID-19 Era. Preprints 2024, 2024092464. https://doi.org/10.20944/preprints202409.2464.v1
García, A. H.; De Sanctis, J. B. Exploring the Contrasts and Similarities of Dengue and SARS-CoV-2 Infections during the COVID-19 Era. Preprints2024, 2024092464. https://doi.org/10.20944/preprints202409.2464.v1
APA Style
García, A. H., & De Sanctis, J. B. (2024). Exploring the Contrasts and Similarities of Dengue and SARS-CoV-2 Infections during the COVID-19 Era. Preprints. https://doi.org/10.20944/preprints202409.2464.v1
Chicago/Turabian Style
García, A. H. and Juan Bautista De Sanctis. 2024 "Exploring the Contrasts and Similarities of Dengue and SARS-CoV-2 Infections during the COVID-19 Era" Preprints. https://doi.org/10.20944/preprints202409.2464.v1
Abstract
Extensive research has been conducted on the SARS-CoV-2 virus in association with various infectious diseases to understand the pathophysiology of the infection and potential co-infections. In tropical countries, exposure to local viruses may alter the course of SARS-CoV-2 infection and coinfection. Notably, only a portion of the antibodies produced against SARS-CoV-2 proteins demonstrate neutralizing properties, and the immune response following natural infection tends to be temporary. In contrast, long-lasting IgG antibodies are common after dengue virus infections. In cases where preexisting antibodies from an initial dengue virus infection bind to a different dengue serotype during a subsequent infection, there is a potential for antibody-dependent enhancement (ADE) and the formation of immune complexes associated with disease severity. Both SARS-CoV-2 and dengue infections can result in immunodeficiency. Viral proteins of both viruses interfere with the host’s IFN-I signaling. Additionally, a cytokine storm can occur after viral infection, impairing a proper response, and autoantibodies against a wide array of proteins can appear during convalescence. Most of the reported autoantibodies are typically short-lived. Vaccines against both viruses alter the immune response, affecting the course of viral infection and enhancing clearance. A comprehensive analysis of both viral infections and pathogenicity is revisited to prevent infection, severity, and mortality.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
