Version 1
: Received: 30 September 2024 / Approved: 1 October 2024 / Online: 1 October 2024 (12:56:38 CEST)
How to cite:
Ray, H.; Weis, C.; Nwaeze, C.; Zhou, V.; Basu, P.; Mitra, A. Development and Control of Biofilms in Diabetic Foot Infections. Preprints2024, 2024100061. https://doi.org/10.20944/preprints202410.0061.v1
Ray, H.; Weis, C.; Nwaeze, C.; Zhou, V.; Basu, P.; Mitra, A. Development and Control of Biofilms in Diabetic Foot Infections. Preprints 2024, 2024100061. https://doi.org/10.20944/preprints202410.0061.v1
Ray, H.; Weis, C.; Nwaeze, C.; Zhou, V.; Basu, P.; Mitra, A. Development and Control of Biofilms in Diabetic Foot Infections. Preprints2024, 2024100061. https://doi.org/10.20944/preprints202410.0061.v1
APA Style
Ray, H., Weis, C., Nwaeze, C., Zhou, V., Basu, P., & Mitra, A. (2024). Development and Control of Biofilms in Diabetic Foot Infections. Preprints. https://doi.org/10.20944/preprints202410.0061.v1
Chicago/Turabian Style
Ray, H., Paramita Basu and Arindam Mitra. 2024 "Development and Control of Biofilms in Diabetic Foot Infections" Preprints. https://doi.org/10.20944/preprints202410.0061.v1
Abstract
Diabetic foot ulcers (DFUs) are a multifactorial pathophysiologic condition that occurs in patients with diabetes mellitus (DM). Approximately 9.1 to 26.1 million people are affected by DFUs annually. This condition can lead to progressive foot infections and, ultimately, foot amputation. Various microbes contribute to DFUs, including methicillin-resistant Staphylococcus. aureus, Pseudomonas aeruginosa, and Escherichia coli can form biofilms composed of complex matrices that create a protective shield around the microorganisms, enhancing their survival and resistance to treatment. Biofilm formation is a critical virulence factor directly associated with the onset and persistence of DFUs. It not only complicates the clinical management of these ulcers but also facilitates antibiotic resistance, necessitating a comprehensive approach to treatment. Effective management strategies must therefore target biofilm formation and the virulence factors associated with these pathogens. By addressing these elements, conventional antibiotics can be rendered more effective in treating diabetic foot ulcers. This approach aims not only to promote wound healing but also to address underlying causes and prevent further complications. This article seeks to highlight the significance of biofilm formation in DFUs, explore methodologies for studying this condition, as well as discuss demographic considerations and treatment options.
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
