PreprintArticleVersion 1This version is not peer-reviewed
Therapeutic Potential of a Dietary Intervention with the Combination of Butyrate, Trehalose, Piceid, and Biochanin a on a Neuropsychiatric Disorder in Mice
Version 1
: Received: 1 October 2024 / Approved: 1 October 2024 / Online: 1 October 2024 (14:45:13 CEST)
How to cite:
Nakashima, M.; Fukumoto, A.; Yoshikawa, S.; Matsuda, S. Therapeutic Potential of a Dietary Intervention with the Combination of Butyrate, Trehalose, Piceid, and Biochanin a on a Neuropsychiatric Disorder in Mice. Preprints2024, 2024100077. https://doi.org/10.20944/preprints202410.0077.v1
Nakashima, M.; Fukumoto, A.; Yoshikawa, S.; Matsuda, S. Therapeutic Potential of a Dietary Intervention with the Combination of Butyrate, Trehalose, Piceid, and Biochanin a on a Neuropsychiatric Disorder in Mice. Preprints 2024, 2024100077. https://doi.org/10.20944/preprints202410.0077.v1
Nakashima, M.; Fukumoto, A.; Yoshikawa, S.; Matsuda, S. Therapeutic Potential of a Dietary Intervention with the Combination of Butyrate, Trehalose, Piceid, and Biochanin a on a Neuropsychiatric Disorder in Mice. Preprints2024, 2024100077. https://doi.org/10.20944/preprints202410.0077.v1
APA Style
Nakashima, M., Fukumoto, A., Yoshikawa, S., & Matsuda, S. (2024). Therapeutic Potential of a Dietary Intervention with the Combination of Butyrate, Trehalose, Piceid, and Biochanin a on a Neuropsychiatric Disorder in Mice. Preprints. https://doi.org/10.20944/preprints202410.0077.v1
Chicago/Turabian Style
Nakashima, M., Sayuri Yoshikawa and Satoru Matsuda. 2024 "Therapeutic Potential of a Dietary Intervention with the Combination of Butyrate, Trehalose, Piceid, and Biochanin a on a Neuropsychiatric Disorder in Mice" Preprints. https://doi.org/10.20944/preprints202410.0077.v1
Abstract
Neuropsychiatric disorders are worldwide public-health concern. Schizophrenia is one of the well-known neuropsychiatric disorders, which may affect millions globally. Maternal immune activation might be one of the key factor for the development of neuropsychiatric disorders. Previously, a mouse model of neuropsychiatric disorders has originally been made, in which poly-I:C, sodium dextran sulfate (DSS) and κ-carrageenan (CGN) were used for the maternal immune activation of mice. In the neuropsychiatric disorder mice, a significant link between biochemical changes of p62 and/or GLAST in the mouse brain and the alteration of experimental behaviors. Therefore, potential therapeutic study has been achieved for the development of effective treatment against neuropsychiatric disorders with using butyric acid, trehalose, piceid, and biochanin A. As a result, some of the combination with these orally available molecules could be effective for the improvement of behavioral alterations as well as biochemical changes of p62 and/or GLAST in the mouse brain. Importantly, the correlation between behavioral score and p62/GLAST protein expression has been again recognized. The significant correlation between pathological behavior and the biochemical alterations would contribute to develop further innovative therapeutics for vaious psychiatric disorders.
Keywords
neuropsychiatric disorder; schizophrenia; behavioral test; autophagy; p62; GLAST; animal model
Subject
Biology and Life Sciences, Food Science and Technology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
