Version 1
: Received: 30 September 2024 / Approved: 1 October 2024 / Online: 2 October 2024 (07:57:34 CEST)
How to cite:
Prouse, T.; Majumder, S.; Majumder, R. Functions of TAM Receptors and Their Ligands Protein S and Gas6 in Atherosclerosis and Cardiovascular Disease. Preprints2024, 2024100083. https://doi.org/10.20944/preprints202410.0083.v1
Prouse, T.; Majumder, S.; Majumder, R. Functions of TAM Receptors and Their Ligands Protein S and Gas6 in Atherosclerosis and Cardiovascular Disease. Preprints 2024, 2024100083. https://doi.org/10.20944/preprints202410.0083.v1
Prouse, T.; Majumder, S.; Majumder, R. Functions of TAM Receptors and Their Ligands Protein S and Gas6 in Atherosclerosis and Cardiovascular Disease. Preprints2024, 2024100083. https://doi.org/10.20944/preprints202410.0083.v1
APA Style
Prouse, T., Majumder, S., & Majumder, R. (2024). Functions of TAM Receptors and Their Ligands Protein S and Gas6 in Atherosclerosis and Cardiovascular Disease. Preprints. https://doi.org/10.20944/preprints202410.0083.v1
Chicago/Turabian Style
Prouse, T., Samarpan Majumder and Rinku Majumder. 2024 "Functions of TAM Receptors and Their Ligands Protein S and Gas6 in Atherosclerosis and Cardiovascular Disease" Preprints. https://doi.org/10.20944/preprints202410.0083.v1
Abstract
Atherosclerosis and cardiovascular disease are associated with high morbidity and mortality in industrialized nations. The Tyro3, Axl, and Mer (TAM) family of receptor tyrosine kinases is involved in amplification or resolution of atherosclerosis pathology and other cardiovascular pathology. The ligands of these receptors, Protein S (PS) and growth arrest specific protein 6 (Gas6), are essential for TAM receptor functions in amplification and resolution of atherosclerosis. The Axl-Gas6 interaction has various effects on cardiovascular disease. Mer and PS dampen inflammation, thereby protecting against atherosclerosis progression. Tyro3, the least studied TAM receptor in cardiovascular disease, appears to protect against fibrosis in post-myocardial infarction injury. Ultimately, PS, Gas6, and TAM receptors present an exciting avenue of potential therapeutic targets against inflammation associated with atherosclerosis and cardiovascular disease.
Keywords
Protein S; Gas6; atherosclerosis; TAM receptors; cardiovascular disease; myocardial infarction; apoptosis
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
