Computational Fluid Dynamic Optimization of Micropatterned Surfaces: Towards Biofunctionalization of Artificial Organs

Wenxuan He; Aminat M. Ibrahim; Abhishek Karmakar; Shivani Tuli; Jonathan Butcher; James F. Antaki

doi:10.20944/preprints202410.0108.v1

Preprint Article Version 1 This version is not peer-reviewed

Version 1 : Received: 1 October 2024 / Approved: 2 October 2024 / Online: 2 October 2024 (10:47:11 CEST)

Modifying surface topography to prevent surface-induced thrombosis in cardiovascular implants allows endothelialization, which is the natural thrombo-resistance of the blood-contacting surfaces and is deemed to be the only long-term hemocompatible material. We have adapted a simulation framework to predict platelet deposition on the modified surface and developed an optimization strategy to promote endothelial retention and limit platelet deposition. Under supraphysiological bulk shear stress, a maximum of 79% linear coverage was achieved. This study concludes that the addition of microtrenches promotes endothelial retention and can be improved through optimal selection of geometric parameters.

LVAD; mechanical valves; thrombosis; endothelial cells; hemocompatibility; Mechanical devices

Engineering, Bioengineering

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Computational Fluid Dynamic Optimization of Micropatterned Surfaces: Towards Biofunctionalization of Artificial Organs

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