Version 1
: Received: 30 September 2024 / Approved: 2 October 2024 / Online: 3 October 2024 (04:02:26 CEST)
How to cite:
Hayrapetyan, V.; Karapetyan, L.; Ghukasyan, L.; Atshemyan, S.; Ghazaryan, H.; Vardanyan, V. S.; Mukuchyan, V.; Arakelyan, A.; Zakharyan, R. Association of Inflammasome Gene Expression Levels with Pathogenesis of Familial Mediterranean Fever in Armenians. Preprints2024, 2024100130. https://doi.org/10.20944/preprints202410.0130.v1
Hayrapetyan, V.; Karapetyan, L.; Ghukasyan, L.; Atshemyan, S.; Ghazaryan, H.; Vardanyan, V. S.; Mukuchyan, V.; Arakelyan, A.; Zakharyan, R. Association of Inflammasome Gene Expression Levels with Pathogenesis of Familial Mediterranean Fever in Armenians. Preprints 2024, 2024100130. https://doi.org/10.20944/preprints202410.0130.v1
Hayrapetyan, V.; Karapetyan, L.; Ghukasyan, L.; Atshemyan, S.; Ghazaryan, H.; Vardanyan, V. S.; Mukuchyan, V.; Arakelyan, A.; Zakharyan, R. Association of Inflammasome Gene Expression Levels with Pathogenesis of Familial Mediterranean Fever in Armenians. Preprints2024, 2024100130. https://doi.org/10.20944/preprints202410.0130.v1
APA Style
Hayrapetyan, V., Karapetyan, L., Ghukasyan, L., Atshemyan, S., Ghazaryan, H., Vardanyan, V. S., Mukuchyan, V., Arakelyan, A., & Zakharyan, R. (2024). Association of Inflammasome Gene Expression Levels with Pathogenesis of Familial Mediterranean Fever in Armenians. Preprints. https://doi.org/10.20944/preprints202410.0130.v1
Chicago/Turabian Style
Hayrapetyan, V., Arsen Arakelyan and Roksana Zakharyan. 2024 "Association of Inflammasome Gene Expression Levels with Pathogenesis of Familial Mediterranean Fever in Armenians" Preprints. https://doi.org/10.20944/preprints202410.0130.v1
Abstract
Familial Mediterranean fever (FMF) is a genetically determined autoinflammatory disease transmitted by an autosomal recessive mechanism. The cause of the nosology is point mutations of the MEFV (Mediterranean FeVer) gene coding for pyrin protein. Inflammasomes are molecular platforms altered in autoinflammatory diseases. The aim of this study was to evaluate the expression of inflammasome genes (p65, Casp-1, MEFV-d2, MEFV-I, NLRP3) in patients with FMF compared to controls to understand the changes that may play a key role in disease development. We found altered expression levels of the full-length MEFV isoform as well as Casp1 and p65 in FMF patients versus controls. This, once again highlighted the significance of inflammasome genes in terms of FMF.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
