Hypothesis
Version 4
This version is not peer-reviewed
Purging Autologous HSCs via Detection of Clonal Mutations
Version 1
: Received: 2 October 2024 / Approved: 2 October 2024 / Online: 2 October 2024 (12:22:05 CEST)
Version 2 : Received: 2 October 2024 / Approved: 3 October 2024 / Online: 3 October 2024 (15:20:18 CEST)
Version 3 : Received: 7 October 2024 / Approved: 8 October 2024 / Online: 8 October 2024 (17:05:08 CEST)
Version 4 : Received: 12 October 2024 / Approved: 14 October 2024 / Online: 14 October 2024 (14:54:01 CEST)
Version 2 : Received: 2 October 2024 / Approved: 3 October 2024 / Online: 3 October 2024 (15:20:18 CEST)
Version 3 : Received: 7 October 2024 / Approved: 8 October 2024 / Online: 8 October 2024 (17:05:08 CEST)
Version 4 : Received: 12 October 2024 / Approved: 14 October 2024 / Online: 14 October 2024 (14:54:01 CEST)
How to cite: Renteln, M. Purging Autologous HSCs via Detection of Clonal Mutations. Preprints 2024, 2024100163. https://doi.org/10.20944/preprints202410.0163.v4 Renteln, M. Purging Autologous HSCs via Detection of Clonal Mutations. Preprints 2024, 2024100163. https://doi.org/10.20944/preprints202410.0163.v4
Abstract
Allogeneic hematopoietic stem cell (HSC) transplants are usually used in cases where patients have active cancerous illness in their bone marrow, but allogeneic transplants can cause graft vs. host disease. If autologous HSCs could be purged of cancer cells, they could then be used for transplantation purposes without concern. It is still controversial whether purging is necessary, but it certainly would alleviate concerns. A novel method of purging is discussed herein that does not require chemotherapy and is targeted for each patient. It could be applied either in vitro or in vivo.
Keywords
purging; autologous bone marrow transplant; hematopoietic stem cells; dual adenoviral transduction; ex vivo and in vivo treatments; personalized oncolytic vector
Subject
Medicine and Pharmacology, Hematology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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