Version 1
: Received: 5 October 2024 / Approved: 6 October 2024 / Online: 7 October 2024 (07:37:25 CEST)
How to cite:
Choate, K. A.; Pratt, E. P.; Jennings, M. J.; Winn, R. J.; Mann, P. B. IDH Mutations in Glioma: Molecular, Cellular, Diagnostic, and Clinical Implications. Preprints2024, 2024100393. https://doi.org/10.20944/preprints202410.0393.v1
Choate, K. A.; Pratt, E. P.; Jennings, M. J.; Winn, R. J.; Mann, P. B. IDH Mutations in Glioma: Molecular, Cellular, Diagnostic, and Clinical Implications. Preprints 2024, 2024100393. https://doi.org/10.20944/preprints202410.0393.v1
Choate, K. A.; Pratt, E. P.; Jennings, M. J.; Winn, R. J.; Mann, P. B. IDH Mutations in Glioma: Molecular, Cellular, Diagnostic, and Clinical Implications. Preprints2024, 2024100393. https://doi.org/10.20944/preprints202410.0393.v1
APA Style
Choate, K. A., Pratt, E. P., Jennings, M. J., Winn, R. J., & Mann, P. B. (2024). IDH Mutations in Glioma: Molecular, Cellular, Diagnostic, and Clinical Implications. Preprints. https://doi.org/10.20944/preprints202410.0393.v1
Chicago/Turabian Style
Choate, K. A., Robert James Winn and Paul Barrie Mann. 2024 "IDH Mutations in Glioma: Molecular, Cellular, Diagnostic, and Clinical Implications" Preprints. https://doi.org/10.20944/preprints202410.0393.v1
Abstract
In 2021, the World Health Organization classified isocitrate dehydrogenase (IDH) mutant gliomas as a distinct subgroup of tumors with genetic changes sufficient to enable a complete diagnosis. Patients with an IDH mutant glioma have improved survival which has been further enhanced by the advent of targeted therapies. IDH enzymes contribute to cellular metabolism, and mutations to specific catalytic residues result in the neomorphic production of D-2-hydroxyglutarate (D-2-HG). The accumulation of D-2-HG results in epigenetic alterations, oncogenesis and impacts the tumor microenvironment via immunological modulations. Here, we summarize the molecular, cellular, and clinical implications of IDH mutations in gliomas as well as current diagnostic techniques.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
