Version 1
: Received: 6 October 2024 / Approved: 7 October 2024 / Online: 7 October 2024 (07:51:40 CEST)
How to cite:
Coskuner-Weber, O.; Cayli, F. N.; Uversky, V. N. Disordered Peptide-Based Design of Intrinsically Disordered Polymers for Biomedical Applications. Preprints2024, 2024100414. https://doi.org/10.20944/preprints202410.0414.v1
Coskuner-Weber, O.; Cayli, F. N.; Uversky, V. N. Disordered Peptide-Based Design of Intrinsically Disordered Polymers for Biomedical Applications. Preprints 2024, 2024100414. https://doi.org/10.20944/preprints202410.0414.v1
Coskuner-Weber, O.; Cayli, F. N.; Uversky, V. N. Disordered Peptide-Based Design of Intrinsically Disordered Polymers for Biomedical Applications. Preprints2024, 2024100414. https://doi.org/10.20944/preprints202410.0414.v1
APA Style
Coskuner-Weber, O., Cayli, F. N., & Uversky, V. N. (2024). Disordered Peptide-Based Design of Intrinsically Disordered Polymers for Biomedical Applications. Preprints. https://doi.org/10.20944/preprints202410.0414.v1
Chicago/Turabian Style
Coskuner-Weber, O., Fatma Nilsu Cayli and Vladimir N. Uversky. 2024 "Disordered Peptide-Based Design of Intrinsically Disordered Polymers for Biomedical Applications" Preprints. https://doi.org/10.20944/preprints202410.0414.v1
Abstract
In biology and medicine, synthetic polymers that mimic intrinsically disordered proteins (IDPs) exhibiting remarkable structural and conformational flexibility due to their lack of stable three-dimensional structures are highly desirable. This conformational flexibility facilitates self-organization, making such polymers highly useful for various biomedical applications. Specifically, intrinsically disordered synthetic polymers show great potential in drug delivery systems, organ transplantation, artificial organ design, and ensuring immune compatibility. There is a pressing need for new synthesis and characterization techniques to develop these polymers which are modeled after intrinsically disordered proteins and can be used for various biomedical purposes. In this paper, we outline our strategies for designing intrinsically disordered synthetic polymers for biomedical applications. These design approaches are inspired by the properties of intrinsically disordered proteins and use of disorder promoting oligopeptides.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
