Version 1
: Received: 7 October 2024 / Approved: 8 October 2024 / Online: 8 October 2024 (13:40:34 CEST)
How to cite:
Denesyuk, A. I.; Denessiouk, K.; Johnson, M. S.; Uversky, V. N. Structural Catalytic Core in Subtilisin-Like Proteins and its Comparison to Trypsin-Like Serine Proteases and Alpha/Beta-Hydrolases. Preprints2024, 2024100597. https://doi.org/10.20944/preprints202410.0597.v1
Denesyuk, A. I.; Denessiouk, K.; Johnson, M. S.; Uversky, V. N. Structural Catalytic Core in Subtilisin-Like Proteins and its Comparison to Trypsin-Like Serine Proteases and Alpha/Beta-Hydrolases. Preprints 2024, 2024100597. https://doi.org/10.20944/preprints202410.0597.v1
Denesyuk, A. I.; Denessiouk, K.; Johnson, M. S.; Uversky, V. N. Structural Catalytic Core in Subtilisin-Like Proteins and its Comparison to Trypsin-Like Serine Proteases and Alpha/Beta-Hydrolases. Preprints2024, 2024100597. https://doi.org/10.20944/preprints202410.0597.v1
APA Style
Denesyuk, A. I., Denessiouk, K., Johnson, M. S., & Uversky, V. N. (2024). Structural Catalytic Core in Subtilisin-Like Proteins and its Comparison to Trypsin-Like Serine Proteases and Alpha/Beta-Hydrolases. Preprints. https://doi.org/10.20944/preprints202410.0597.v1
Chicago/Turabian Style
Denesyuk, A. I., Mark S. Johnson and Vladimir N. Uversky. 2024 "Structural Catalytic Core in Subtilisin-Like Proteins and its Comparison to Trypsin-Like Serine Proteases and Alpha/Beta-Hydrolases" Preprints. https://doi.org/10.20944/preprints202410.0597.v1
Abstract
Subtilisin-like proteins are serine proteases that use two types of catalytic triads: Ser-His-Asp and Ser-Glu-Asp. Here, we investigate the two known families of subtilisin-like proteins, the subtilases (Ser-His-Asp triad) and the serine-carboxyl proteinases (Ser-Glu-Asp triad), and describe local structural arrangements (cores) that govern the catalytic residues in these proteins. We show separation of the cores into conserved structural zones, which can be repeatedly found in different structures, and compare the structural cores in subtilisin-like proteins with those in trypsin-like serine proteases and alpha/beta-hydrolases.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.