PreprintArticleVersion 1This version is not peer-reviewed
Investigating the Influence of Body Mass Index on Organs at Risk Doses for Adjuvant HDR Vaginal Cuff Brachytherapy In Patients with Early Stage Endometrial Carcinoma
Version 1
: Received: 7 October 2024 / Approved: 8 October 2024 / Online: 8 October 2024 (14:55:58 CEST)
How to cite:
Kirsch-Mangu, A. T.; Pop, D. C.; Tipcu, A.; Avasi, A. R.; Ordeanu, C.; Coza, O. F.; Irimie, A. Investigating the Influence of Body Mass Index on Organs at Risk Doses for Adjuvant HDR Vaginal Cuff Brachytherapy In Patients with Early Stage Endometrial Carcinoma. Preprints2024, 2024100606. https://doi.org/10.20944/preprints202410.0606.v1
Kirsch-Mangu, A. T.; Pop, D. C.; Tipcu, A.; Avasi, A. R.; Ordeanu, C.; Coza, O. F.; Irimie, A. Investigating the Influence of Body Mass Index on Organs at Risk Doses for Adjuvant HDR Vaginal Cuff Brachytherapy In Patients with Early Stage Endometrial Carcinoma. Preprints 2024, 2024100606. https://doi.org/10.20944/preprints202410.0606.v1
Kirsch-Mangu, A. T.; Pop, D. C.; Tipcu, A.; Avasi, A. R.; Ordeanu, C.; Coza, O. F.; Irimie, A. Investigating the Influence of Body Mass Index on Organs at Risk Doses for Adjuvant HDR Vaginal Cuff Brachytherapy In Patients with Early Stage Endometrial Carcinoma. Preprints2024, 2024100606. https://doi.org/10.20944/preprints202410.0606.v1
APA Style
Kirsch-Mangu, A. T., Pop, D. C., Tipcu, A., Avasi, A. R., Ordeanu, C., Coza, O. F., & Irimie, A. (2024). Investigating the Influence of Body Mass Index on Organs at Risk Doses for Adjuvant HDR Vaginal Cuff Brachytherapy In Patients with Early Stage Endometrial Carcinoma. Preprints. https://doi.org/10.20944/preprints202410.0606.v1
Chicago/Turabian Style
Kirsch-Mangu, A. T., Ovidiu Florin Coza and Alexandru Irimie. 2024 "Investigating the Influence of Body Mass Index on Organs at Risk Doses for Adjuvant HDR Vaginal Cuff Brachytherapy In Patients with Early Stage Endometrial Carcinoma" Preprints. https://doi.org/10.20944/preprints202410.0606.v1
Abstract
Background: This study aims to investigate the influence of Body Mass Index (BMI) on the doses received by organs at risk (OAR) during high-dose-rate (HDR) vaginal cuff brachytherapy in pa-tients diagnosed with early-stage endometrial carcinoma. Understanding the relationship be-tween BMI and OAR doses could enhance treatment planning and minimize complications.
Methods: We collected brachytherapy data for 242 endometrial cancer patients treated with ad-juvant HDR vaginal cuff brachytherapy. The patients were categorized based on their BMI into normal weight, overweight, and obese groups. Dosimetric data were collected for OARs, includ-ing the bladder, rectum, and sigmoid colon and also for dose fractionation, D90 and the active length of the brachytherapy cylinder. The analysis included comparing the doses received by each organ across different BMI categories using appropriate statistical methods
Results: Preliminary findings indicated a significant variation in the doses to OARs correlating with BMI classifications. Obese patients exhibited slightly higher mean doses to the rectum and bladder compared to those with a normal BMI. The statistical analysis demonstrated that as BMI increased, the dose to these organs at risk also tended to increase, suggesting a need for ad-justed treatment planning strategies in this population.
Conclusions: Obesity is a key concern in endometrial cancer patients, with higher BMI linked to slightly increased doses to the rectum and sigmoid, though treatment remained homogeneously delivered.Future work should focus on refining dosimetric techniques and exploring strategies to mitigate OAR exposure in patients with higher BMI.
Keywords
Endometrial cancer; Body mass index; Vaginal cuff brachytherapy; Three-dimensional vaginal cuff brachytherapy; Dosimetry; Obesity
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
