Modeling the Dynamics of Pleasure, Pain, and Stress: A Neurochemical Perspective

José Ignacio

doi:10.20944/preprints202410.0623.v1

Preprint Article Version 1 This version is not peer-reviewed

Version 1 : Received: 7 October 2024 / Approved: 8 October 2024 / Online: 9 October 2024 (08:40:02 CEST)

This article presents a mathematical model that captures the temporal dynamics of efficiencies in the responses to pleasure and pain, represented by $k_P(t)$ and $k_D(t)$, as well as the interaction factor $k_{PD}(t)$ between cortisol and dopamine. The model allows for the analysis of how these parameters evolve over time as a function of an individual's activities and physiological states, incorporating processes of tolerance, sensitization, and homeostasis. We present the updated differential equations, qualitative analyses, potential simulation scenarios, implications, and potential applications of the model.

Pleasure-pain dynamics; Neurochemical modeling; Dopamine-cortisol interaction; Tolerance and sensitization; Stress response adaptation

Biology and Life Sciences, Neuroscience and Neurology

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Modeling the Dynamics of Pleasure, Pain, and Stress: A Neurochemical Perspective

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