Polymorphisms of the Vitamin D Binding Protein (VDBP) and Free vitamin D in pediatric and young adult patients with cystic fibrosis

Paula Quesada-Colloto; Noelia Avello-Llano; Ruth García-Romero; María Garriga-García; Marina Álvarez-Beltrán; Ana Isabel Reyes-Domínguez; Ana Estefanía Fernández-Lorenzo; Helena Gil-Peña; Carlos Gómez-Alonso; Carmen García-Gil-Albert; Saioa Vicente-Santamaria; Luis Peña-Quintana; Juan José Díaz-Martin; José Ramon Gutiérrez-Martínez; Carmen Martin-Fernández; Agustín De la Mano-Hernández; Ana Moreno-Álvarez; David González-Jiménez

doi:10.20944/preprints202410.0710.v1

How to cite: Quesada-Colloto, P.; Avello-Llano, N.; García-Romero, R.; Garriga-García, M.; Álvarez-Beltrán, M.; Reyes-Domínguez, A. I.; Fernández-Lorenzo, A. E.; Gil-Peña, H.; Gómez-Alonso, C.; García-Gil-Albert, C.; Vicente-Santamaria, S.; Peña-Quintana, L.; Díaz-Martin, J. J.; Gutiérrez-Martínez, J. R.; Martin-Fernández, C.; Mano-Hernández, A. D. L.; Moreno-Álvarez, A.; González-Jiménez, D. Polymorphisms of the Vitamin D Binding Protein (VDBP) and Free vitamin D in pediatric and young adult patients with cystic fibrosis. Preprints 2024, 2024100710. https://doi.org/10.20944/preprints202410.0710.v1 Quesada-Colloto, P.; Avello-Llano, N.; García-Romero, R.; Garriga-García, M.; Álvarez-Beltrán, M.; Reyes-Domínguez, A. I.; Fernández-Lorenzo, A. E.; Gil-Peña, H.; Gómez-Alonso, C.; García-Gil-Albert, C.; Vicente-Santamaria, S.; Peña-Quintana, L.; Díaz-Martin, J. J.; Gutiérrez-Martínez, J. R.; Martin-Fernández, C.; Mano-Hernández, A. D. L.; Moreno-Álvarez, A.; González-Jiménez, D. Polymorphisms of the Vitamin D Binding Protein (VDBP) and Free vitamin D in pediatric and young adult patients with cystic fibrosis. Preprints 2024, 2024100710. https://doi.org/10.20944/preprints202410.0710.v1

Abstract

Objetives/Background: Vitamin D Binding Protein (VDBP) and free vitamin D are new markers that are being studied as a possible markers of vitamin D status. The main aim of our study was to analyse the VDBP genotype and quantify the levels of VDBP and free vitamin D in a sample of cystic fibrosis (CF) patients. Methods: Multicentre, cross-sectional and prospective study includ-ing patients with CF, exocrine pancreatic insufficiency who were clinically stable. We investigated vitamin D levels (total and free) and the different VDBP haplotypes. Free vitamin D levels were measured using an electro-chemiluminescence assay. Results: A sample of 48 patients was ob-tained (52% male; median age 13.8 years). The most common allele of VDBP was Gc1s (72%)>Gc2 (52%)>Gc1f (27%). Median calcidiol was 21.2 ng/ml (IR 15.3 - 26.9), 81% had levels in the insufficiency range: 23 patients (48%) below 20 ng/ml, and 16 (33%) between 20 and 30 ng/ml. The median free vitamin D level was 4.2 pg/ml (IR 3.9 – 5.6). A positive correlation was observed between calcidiol and free vitamin D levels (r=0.871; p

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Polymorphisms of the Vitamin D Binding Protein (VDBP) and Free vitamin D in pediatric and young adult patients with cystic fibrosis

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