PreprintArticleVersion 1This version is not peer-reviewed
Assessment of Treatment Outcomes in Patients with Breast Cancer Who Underwent Mastectomy and Immediate Breast Reconstruction with Sparing of the Areola-Nipple Complex – Single-Center Analysis
Version 1
: Received: 4 October 2024 / Approved: 4 October 2024 / Online: 9 October 2024 (17:10:38 CEST)
How to cite:
Stachura, W.; Nowikiewicz, M.; Zdrenka, M.; Szymankiewicz, M.; Glowacka-Mrotek, I.; Tarkowska, M.; Szylberg, Ł.; Zegarski, W.; Nowikiewicz, T. Assessment of Treatment Outcomes in Patients with Breast Cancer Who Underwent Mastectomy and Immediate Breast Reconstruction with Sparing of the Areola-Nipple Complex – Single-Center Analysis. Preprints2024, 2024100723. https://doi.org/10.20944/preprints202410.0723.v1
Stachura, W.; Nowikiewicz, M.; Zdrenka, M.; Szymankiewicz, M.; Glowacka-Mrotek, I.; Tarkowska, M.; Szylberg, Ł.; Zegarski, W.; Nowikiewicz, T. Assessment of Treatment Outcomes in Patients with Breast Cancer Who Underwent Mastectomy and Immediate Breast Reconstruction with Sparing of the Areola-Nipple Complex – Single-Center Analysis. Preprints 2024, 2024100723. https://doi.org/10.20944/preprints202410.0723.v1
Stachura, W.; Nowikiewicz, M.; Zdrenka, M.; Szymankiewicz, M.; Glowacka-Mrotek, I.; Tarkowska, M.; Szylberg, Ł.; Zegarski, W.; Nowikiewicz, T. Assessment of Treatment Outcomes in Patients with Breast Cancer Who Underwent Mastectomy and Immediate Breast Reconstruction with Sparing of the Areola-Nipple Complex – Single-Center Analysis. Preprints2024, 2024100723. https://doi.org/10.20944/preprints202410.0723.v1
APA Style
Stachura, W., Nowikiewicz, M., Zdrenka, M., Szymankiewicz, M., Glowacka-Mrotek, I., Tarkowska, M., Szylberg, Ł., Zegarski, W., & Nowikiewicz, T. (2024). Assessment of Treatment Outcomes in Patients with Breast Cancer Who Underwent Mastectomy and Immediate Breast Reconstruction with Sparing of the Areola-Nipple Complex – Single-Center Analysis. Preprints. https://doi.org/10.20944/preprints202410.0723.v1
Chicago/Turabian Style
Stachura, W., Wojciech Zegarski and Tomasz Nowikiewicz. 2024 "Assessment of Treatment Outcomes in Patients with Breast Cancer Who Underwent Mastectomy and Immediate Breast Reconstruction with Sparing of the Areola-Nipple Complex – Single-Center Analysis" Preprints. https://doi.org/10.20944/preprints202410.0723.v1
Abstract
Purpose: Despite significant improvements in early detection of breast cancer, some patients still require mastectomy. One clinical problem currently being analyzed is the possibility of preserving the areola-nipple complex (NAC). The aim of this study was to evaluate the treatment results of breast cancer patients who underwent mastectomy with immediate breast reconstruction with sparing of the NAC.
Methods: 335 patients who underwent mastectomy with breast reconstruction – with sparing (group I: 300 patients) or removal of NAC (group II: 35 patients), treated in the period 07.2014-06.2020. In the study groups, the length of overall survival (OS) and recurrence-free survival (RFS) were determined – up to 24 months after the end of treatment (short-term results) and up to 80 months (long-term results). The mean follow-up time of patients was 55.6 ± 19.7 months.
Results: In 50 patients (14.9%), recurrence of neoplastic disease was observed (in group I: 14.7%, in group II: 17.1%; p=0.6972). It was most often a recurrence of cancer in the scar after mastectomy – in 25 patients (respectively: 7.7% vs 5.7%; p=0.6775) or distant metastases – in 16 patients (4.0% vs 11.4%; p=0.051). A total of 10 deaths were observed (6 – 2.0% vs 4 – 11.4%; p=0.0019). A total of 37 patients (10.7% vs 14.3%) required removal of their implant, mainly due to symptoms of infection – in 24 cases (7.3% vs 5.7%).
Conclusion: Preserving the NAC is a safe therapeutic procedure in patients undergoing mastectomy with the option of reconstructive treatment. In both groups of patients, similar early and late treatment results were obtained.
Keywords
breast cancer; skin-sparing mastectomy and nipple-areola complex; early and late treatment results
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
,
,
