Version 1
: Received: 10 October 2024 / Approved: 11 October 2024 / Online: 11 October 2024 (11:01:47 CEST)
How to cite:
Chandra, M. M. Developmental Origins of Non-Communicable Chronic Diseases: Role of Fetal Undernutrition and Gut Dysbiosis in Infancy. Preprints2024, 2024100865. https://doi.org/10.20944/preprints202410.0865.v1
Chandra, M. M. Developmental Origins of Non-Communicable Chronic Diseases: Role of Fetal Undernutrition and Gut Dysbiosis in Infancy. Preprints 2024, 2024100865. https://doi.org/10.20944/preprints202410.0865.v1
Chandra, M. M. Developmental Origins of Non-Communicable Chronic Diseases: Role of Fetal Undernutrition and Gut Dysbiosis in Infancy. Preprints2024, 2024100865. https://doi.org/10.20944/preprints202410.0865.v1
APA Style
Chandra, M. M. (2024). Developmental Origins of Non-Communicable Chronic Diseases: Role of Fetal Undernutrition and Gut Dysbiosis in Infancy. Preprints. https://doi.org/10.20944/preprints202410.0865.v1
Chicago/Turabian Style
Chandra, M. M. 2024 "Developmental Origins of Non-Communicable Chronic Diseases: Role of Fetal Undernutrition and Gut Dysbiosis in Infancy" Preprints. https://doi.org/10.20944/preprints202410.0865.v1
Abstract
Globally, there is increasing prevalence of non- communicable chronic diseases (NCCD) like obesity, metabolic syndrome, type2 diabetes mellitus (T2DM), hypertension, allergic asthma and neuro-developmental/psychiatric problems making NCCD a leading cause of disability, morbidity and mortality . Some of these NCCD are presenting at a younger age especially in the socio-economically disadvantaged communities of affluent countries, and in low and middle -income countries undergoing industrialization and socioeconomic transition.to more economic prosperity. NCCD are often attributed to unhealthy personal lifestyles, but there may be more at play.
Through a case report-based discussion, I will illustrate how environmental exposures during the critical window of life, including in utero and early infancy, can significantly influence health as an adult . I will discuss how establishment of a rich and diverse symbiotic gut microbiota in the first three years of life promotes health while a loss of diversity and abundance of beneficial symbiotic gut microbes can predispose to aforementioned NCCD , and the best practices to establish a symbiotic gut.
Keywords
DOHaD; Gut microbiome; Dysbiosis; Non-communicable diseases
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
