Version 1
: Received: 11 October 2024 / Approved: 11 October 2024 / Online: 11 October 2024 (11:16:43 CEST)
How to cite:
Vornic, I.; Buciu, V.; Furau, C. G.; Gaje, P. N.; Ceausu, R. A.; Dumitru, C.-S.; Barb, A. C.; Novacescu, D.; Cumpanas, A. A.; Latcu, S. C.; Cut, T. G.; Zara, F. Oxidative Stress and Placental Pathogenesis: A Contemporary Overview on Potential Biomarkers and Emerging Therapeutics. Preprints2024, 2024100912. https://doi.org/10.20944/preprints202410.0912.v1
Vornic, I.; Buciu, V.; Furau, C. G.; Gaje, P. N.; Ceausu, R. A.; Dumitru, C.-S.; Barb, A. C.; Novacescu, D.; Cumpanas, A. A.; Latcu, S. C.; Cut, T. G.; Zara, F. Oxidative Stress and Placental Pathogenesis: A Contemporary Overview on Potential Biomarkers and Emerging Therapeutics. Preprints 2024, 2024100912. https://doi.org/10.20944/preprints202410.0912.v1
Vornic, I.; Buciu, V.; Furau, C. G.; Gaje, P. N.; Ceausu, R. A.; Dumitru, C.-S.; Barb, A. C.; Novacescu, D.; Cumpanas, A. A.; Latcu, S. C.; Cut, T. G.; Zara, F. Oxidative Stress and Placental Pathogenesis: A Contemporary Overview on Potential Biomarkers and Emerging Therapeutics. Preprints2024, 2024100912. https://doi.org/10.20944/preprints202410.0912.v1
APA Style
Vornic, I., Buciu, V., Furau, C. G., Gaje, P. N., Ceausu, R. A., Dumitru, C. S., Barb, A. C., Novacescu, D., Cumpanas, A. A., Latcu, S. C., Cut, T. G., & Zara, F. (2024). Oxidative Stress and Placental Pathogenesis: A Contemporary Overview on Potential Biomarkers and Emerging Therapeutics. Preprints. https://doi.org/10.20944/preprints202410.0912.v1
Chicago/Turabian Style
Vornic, I., Talida Georgiana Cut and Flavia Zara. 2024 "Oxidative Stress and Placental Pathogenesis: A Contemporary Overview on Potential Biomarkers and Emerging Therapeutics" Preprints. https://doi.org/10.20944/preprints202410.0912.v1
Abstract
Oxidative stress (OS) plays a crucial role in placental pathogenesis and pregnancy-related complications. This review explores OS's impact on placental development and function, focusing on novel biomarkers for early detection of at-risk pregnancies and emerging therapeutic strategies. We analyzed recent research on OS in placental pathophysiology, examining its sources, mechanisms, and effects. While trophoblast invasion under low-oxygen conditions and hypoxia-induced OS regulate physiological placental development, excessive OS can lead to complications like miscarriage, preeclampsia, and intrauterine growth restriction. Promising OS biomarkers, including malondialdehyde, 8-isoprostane, and the sFlt-1/PlGF ratio, show potential for early detection of pregnancy complications. Therapeutic strategies targeting OS, such as mitochondria-targeted antioxidants, Nrf2 activators, and gasotransmitter therapies, demonstrate encouraging preclinical results. However, clinical translation remains challenging. Future research should focus on validating these biomarkers in large-scale studies and developing personalized therapies to modulate placental OS. Emerging approaches like extracellular vesicle-based therapies and nanomedicine warrant further investigation for both diagnostic and therapeutic applications in pregnancy-related complications. Integrating OS biomarkers with other molecular and cellular markers offers improved potential for early identification of at-risk pregnancies.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
