Version 1
: Received: 11 October 2024 / Approved: 11 October 2024 / Online: 12 October 2024 (02:35:04 CEST)
How to cite:
Paraskevaidis, I.; Kourek, C.; Farmakis, D.; Tsougos, E. Mitochondrial Dysfunction in Cardiac Disease: The Fort Fell. Preprints2024, 2024100940. https://doi.org/10.20944/preprints202410.0940.v1
Paraskevaidis, I.; Kourek, C.; Farmakis, D.; Tsougos, E. Mitochondrial Dysfunction in Cardiac Disease: The Fort Fell. Preprints 2024, 2024100940. https://doi.org/10.20944/preprints202410.0940.v1
Paraskevaidis, I.; Kourek, C.; Farmakis, D.; Tsougos, E. Mitochondrial Dysfunction in Cardiac Disease: The Fort Fell. Preprints2024, 2024100940. https://doi.org/10.20944/preprints202410.0940.v1
APA Style
Paraskevaidis, I., Kourek, C., Farmakis, D., & Tsougos, E. (2024). Mitochondrial Dysfunction in Cardiac Disease: The Fort Fell. Preprints. https://doi.org/10.20944/preprints202410.0940.v1
Chicago/Turabian Style
Paraskevaidis, I., Dimitrios Farmakis and Elias Tsougos. 2024 "Mitochondrial Dysfunction in Cardiac Disease: The Fort Fell" Preprints. https://doi.org/10.20944/preprints202410.0940.v1
Abstract
Myocardial cells and extracellular matrix fulfil their goal thanks to the energetic availability. Indeed, mechanical and electrical properties of the heart are strongly depended on the energetic production-consumption equilibrium. The produced energy is used under several forms including kinetic, dynamic, thermal energy etc. Notably, as the time goes by; aging as well as in case of heart failure, although total energy remains almost constant the contribution of each energetic form is altered. Thermal energy is increased, whereas the dynamic and kinetic energy are decreased and hence unable to satisfy adequately the cardiac work. Consequently, toxic products, unfolded /misfolded proteins, free radicals etc. are accumulated within the myocardium. Myocardial cell contraction – relaxation coupling, ion exchange, cell growth etc. function is failed, control of cell apoptosis and necrosis is lacking and cardiac micro and macro-architecture change is the final result. Energy production and consumption depends on cardiac metabolic resources and on the functional status of the cardiac silhouette including cardiomyocytes and non-cardiomyocytes cells and their metabolic - energetic behavior. Mitochondria, are intra-cellular organelles producing more than 95% of ATP and fulfill all the above prerequisites being thus very important and as such we have to better understand their anatomy, function and homeostatic properties.
Keywords
heart failure; mitochondria; cardiac disease; energy
Subject
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
