Version 1
: Received: 11 October 2024 / Approved: 12 October 2024 / Online: 12 October 2024 (09:58:43 CEST)
How to cite:
Ahmed, R. The Role of Two-Dimensional NMR Spectroscopy( 2D NMR Spectroscopy )in Pharmaceutical Research: Applications, Advancements, and Future Directions. Preprints2024, 2024100969. https://doi.org/10.20944/preprints202410.0969.v1
Ahmed, R. The Role of Two-Dimensional NMR Spectroscopy( 2D NMR Spectroscopy )in Pharmaceutical Research: Applications, Advancements, and Future Directions. Preprints 2024, 2024100969. https://doi.org/10.20944/preprints202410.0969.v1
Ahmed, R. The Role of Two-Dimensional NMR Spectroscopy( 2D NMR Spectroscopy )in Pharmaceutical Research: Applications, Advancements, and Future Directions. Preprints2024, 2024100969. https://doi.org/10.20944/preprints202410.0969.v1
APA Style
Ahmed, R. (2024). The Role of Two-Dimensional NMR Spectroscopy( 2D NMR Spectroscopy )in Pharmaceutical Research: Applications, Advancements, and Future Directions. Preprints. https://doi.org/10.20944/preprints202410.0969.v1
Chicago/Turabian Style
Ahmed, R. 2024 "The Role of Two-Dimensional NMR Spectroscopy( 2D NMR Spectroscopy )in Pharmaceutical Research: Applications, Advancements, and Future Directions" Preprints. https://doi.org/10.20944/preprints202410.0969.v1
Abstract
Two-Dimensional Nuclear Magnetic Resonance (2D NMR) spectroscopy has become a cornerstone in pharmaceutical research, offering enhanced structural elucidation capabilities for complex molecules. This technique overcomes the limitations of one-dimensional (1D) NMR by providing detailed insights into molecular interactions through the use of advanced spectroscopic methods like COSY, HSQC, and HMBC. In pharmaceutical applications, 2D NMR plays a crucial role in drug characterization, quality control, formulation development, and the structural analysis of natural products. Recent technological advancements such as high-field spectrometers and cryogenic probes have further improved the sensitivity and resolution of 2D NMR, making it indispensable for ensuring drug quality and intellectual property protection. This article delves into the principles and applications of 2D NMR in the pharmaceutical industry, highlighting its critical contributions to drug discovery, development, and quality assurance. Additionally, it addresses the future prospects of 2D NMR in areas like metabolomics, structural biology, and the development of new analytical tools. Despite its numerous advantages, 2D NMR presents challenges such as high operational costs, complexity in data analysis, and sensitivity issues when dealing with low-concentration samples. The article concludes by discussing the ongoing advancements in 2D NMR technology and its evolving role in pharmaceutical innovation.
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
