Real-Life Use of Filgotinib in Rheumatoid arthritis:A Retrospective Cohort Study

How to cite: Raimondo, V.; Caminiti, M.; Olivo, D.; Gigliotti, P.; L'Andolina, M.; Muto, P.; Pellegrini, R.; Varcasia, G.; Bruno, C.; Massaro, L.; Pagano Mariano, G.; Luppino, J. M. E.; Cirillo, M.; Caira, V.; Calabria, M.; Ciaffi, J.; Ferri, C.; Ursini, F. Real-Life Use of Filgotinib in Rheumatoid arthritis:A Retrospective Cohort Study. Preprints 2024, 2024101012. https://doi.org/10.20944/preprints202410.1012.v1 Raimondo, V.; Caminiti, M.; Olivo, D.; Gigliotti, P.; L'Andolina, M.; Muto, P.; Pellegrini, R.; Varcasia, G.; Bruno, C.; Massaro, L.; Pagano Mariano, G.; Luppino, J. M. E.; Cirillo, M.; Caira, V.; Calabria, M.; Ciaffi, J.; Ferri, C.; Ursini, F. Real-Life Use of Filgotinib in Rheumatoid arthritis:A Retrospective Cohort Study. Preprints 2024, 2024101012. https://doi.org/10.20944/preprints202410.1012.v1

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MDPI and ACS Style

Raimondo, V.; Caminiti, M.; Olivo, D.; Gigliotti, P.; L'Andolina, M.; Muto, P.; Pellegrini, R.; Varcasia, G.; Bruno, C.; Massaro, L.; Pagano Mariano, G.; Luppino, J. M. E.; Cirillo, M.; Caira, V.; Calabria, M.; Ciaffi, J.; Ferri, C.; Ursini, F. Real-Life Use of Filgotinib in Rheumatoid arthritis:A Retrospective Cohort Study. Preprints 2024, 2024101012. https://doi.org/10.20944/preprints202410.1012.v1

APA Style

Raimondo, V., Caminiti, M., Olivo, D., Gigliotti, P., L'Andolina, M., Muto, P., Pellegrini, R., Varcasia, G., Bruno, C., Massaro, L., Pagano Mariano, G., Luppino, J. M. E., Cirillo, M., Caira, V., Calabria, M., Ciaffi, J., Ferri, C., & Ursini, F. (2024). Real-Life Use of Filgotinib in Rheumatoid arthritis:A Retrospective Cohort Study. Preprints. https://doi.org/10.20944/preprints202410.1012.v1

Chicago/Turabian Style

Raimondo, V., Clodoveo Ferri and Francesco Ursini. 2024 "Real-Life Use of Filgotinib in Rheumatoid arthritis:A Retrospective Cohort Study" Preprints. https://doi.org/10.20944/preprints202410.1012.v1

Abstract

Background: In the aftermath of the ORAL Surveillance trial, real-world studies are needed to elucidate the effectiveness and safety of Janus kinase inhibitors (JAKis) in routine clinical practice. Methods: We performed a multicenter, retrospective cohort study investigating the real-life effectiveness and safety of filgotinib, a novel JAK1 inhibitor, in adult patients with rheumatoid arthritis (RA). Demographic information, disease characteristics, prior treatment history, and comorbid conditions, were retrieved from clinical records at baseline (T0) and after 3 (T3) and 6 months (T6) of treatment. Results: A total of 82 patients (63 women) agreed to participate in the study, of which 39 (47.6%) were older than 65 years. Average RA duration was 13 ± 9 years; 19 patients (23.1%) were current or former smokers and 4 patients (4.9%) had a past history of cardiovascular events. Most patients had previously received at least one biologic disease-modifying antirheumatic drug (range: 1–6+); in addition, 11 patients (13.4%) had been already exposed to another JAKi. During the follow-up, 7 patients discontinued treatment due to primary failure (n = 3) or adverse events (n = 4). Significant reductions in pain and number of tender and swollen joints were observed at T3 and T6. A relevant proportion of patients achieved DAS28-CRP remission at T3 and T6 (46.3% and 66.2%, respectively). Conclusion: Our data provide additional insight into the effectiveness and safety of filgotinib in a real-world setting, even among patients with difficult-to-treat RA and a high prevalence of cardiovascular risk factors.

Keywords

Rheumatoid Arhtritis; JAK Inhibitors; Filgotinib

Subject

Medicine and Pharmacology, Medicine and Pharmacology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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