Preprint Article Version 1 This version is not peer-reviewed

Fluorescein Antiseptic Solution Efficacy Assessment for Full-Thickness Skin Graft Management, in Cancer Patients: A Randomized Controlled Trial

Tiziano Pallara
* ORCID logo ,
Francesco Saverio Loria
,
Lodovico Odak
,
Lorenzo Calabrese
,
Francesca Sperati
ORCID logo ,
Marinella Tedesco
,
Antonio Bonadies
ORCID logo ,
Paola Parisi
,
Elena Rita Govoni
,
Emilia Migliano
Version 1 : Received: 13 October 2024 / Approved: 15 October 2024 / Online: 17 October 2024 (09:51:37 CEST)

How to cite: Pallara, T.; Loria, F. S.; Odak, L.; Calabrese, L.; Sperati, F.; Tedesco, M.; Bonadies, A.; Parisi, P.; Govoni, E. R.; Migliano, E. Fluorescein Antiseptic Solution Efficacy Assessment for Full-Thickness Skin Graft Management, in Cancer Patients: A Randomized Controlled Trial. Preprints 2024, 2024101154. https://doi.org/10.20944/preprints202410.1154.v1 Pallara, T.; Loria, F. S.; Odak, L.; Calabrese, L.; Sperati, F.; Tedesco, M.; Bonadies, A.; Parisi, P.; Govoni, E. R.; Migliano, E. Fluorescein Antiseptic Solution Efficacy Assessment for Full-Thickness Skin Graft Management, in Cancer Patients: A Randomized Controlled Trial. Preprints 2024, 2024101154. https://doi.org/10.20944/preprints202410.1154.v1

Abstract

The management of skin cancer presents challenges in reconstructive surgery to achieve the best patient outcome and rapid wound healing. The most used antiseptic in pre and post operative care is Povidone Iodine solution. However, valid antiseptic alternatives should be considered. The primary endpoint of our study was to achieve the best healing in patients receiving fluorescein solution versus two comparator arms (Eosin and Povidone-Iodine).182 patients were enrolled and divided into three randomized groups according to the type of antiseptic solution received: Fluorescein (n = 63), Eosin (n= 60), and Povidone-Iodine (n = 59). To assess the endpoint of our study the ASEPSIS score was used to objectively evaluate graft healing. Results of the ASEPSIS score for each group were analyzed. The comparison demonstrated that there was no statistically significant difference among the three groups regarding the endpoint of our study, thus between fluorescein and povidone-iodine (p = 0.89), eosin and fluorescein (p = 0.54), and eosin and povidone-iodine (p = 0.81). Patients responded positively to the use of the Fluorescein antiseptic solution, although no more than the others. This study suggests that this type of antiseptic can be successfully used in skin graft management.

Keywords

skin cancer; melanoma; Fluorescein solution; povidone-iodine; eosin; asepsis score; full-thickness skin graft; tie-over dressing

Subject

Medicine and Pharmacology, Dermatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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