Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications

Tatiana Zubareva; Ekaterina Mironova; Anna Panfilova; Yulia Krylova; Gianluigi Mazzoccoli; Maria Greta Pia Marasco; Igor Kvetnoy; Peter Yablonsky

doi:10.20944/preprints202410.1408.v1

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preprints.org > biology and life sciences > aging > doi: 10.20944/preprints202410.1408.v1

Preprint Review Version 1 This version is not peer-reviewed

Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications

^* ,

Maria Greta Pia Marasco

Igor Kvetnoy

Peter Yablonsky

Version 1 : Received: 17 October 2024 / Approved: 17 October 2024 / Online: 18 October 2024 (02:49:46 CEST)

How to cite: Zubareva, T.; Mironova, E.; Panfilova, A.; Krylova, Y.; Mazzoccoli, G.; Marasco, M. G. P.; Kvetnoy, I.; Yablonsky, P. Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications. Preprints 2024, 2024101408. https://doi.org/10.20944/preprints202410.1408.v1 Zubareva, T.; Mironova, E.; Panfilova, A.; Krylova, Y.; Mazzoccoli, G.; Marasco, M. G. P.; Kvetnoy, I.; Yablonsky, P. Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications. Preprints 2024, 2024101408. https://doi.org/10.20944/preprints202410.1408.v1

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MDPI and ACS Style

Zubareva, T.; Mironova, E.; Panfilova, A.; Krylova, Y.; Mazzoccoli, G.; Marasco, M. G. P.; Kvetnoy, I.; Yablonsky, P. Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications. Preprints 2024, 2024101408. https://doi.org/10.20944/preprints202410.1408.v1

APA Style

Zubareva, T., Mironova, E., Panfilova, A., Krylova, Y., Mazzoccoli, G., Marasco, M. G. P., Kvetnoy, I., & Yablonsky, P. (2024). Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications. Preprints. https://doi.org/10.20944/preprints202410.1408.v1

Chicago/Turabian Style

Zubareva, T., Igor Kvetnoy and Peter Yablonsky. 2024 "Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications" Preprints. https://doi.org/10.20944/preprints202410.1408.v1

Abstract

This article reviews the contemporary understanding of the functional role of connexins in intercellular communications, their involvement in maintaining cellular and tissue homeostasis, and in aging-associated respiratory disease pathogenesis. Connexins are discussed as potential therapeutic targets. The review particularly focuses on the involvement of gap junctions connexins and hemichannels in the transfer of calcium ions, metabolite molecules, ATP and mitochondria through the cell membrane. Various disorders in the regulation of intercellular communication can heavily contribute to the pathogenesis of multiple diseases, including respiratory system diseases. A deeper understanding of molecular mechanisms underlying the activities of various connexins in gap junction channels will enable the prospective development of therapeutic approaches using either inhibiting or stimulating the activities of a certain connexin, considering its critical functions in intercellular communications on the whole.

Keywords

connexin; Cx43; Cx37; connexon; gap junction; intercellular communications; signaling molecules; respiratory system diseases; target therapy

Subject

Biology and Life Sciences, Aging

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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