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Management of Post-Surgical Pain and Postural Dysfunction Through Focused Mechano-Acoustic Vibrations: a Pilot Observational Study

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Submitted:

23 October 2024

Posted:

23 October 2024

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Abstract
Background/Objectives: Nowadays there is a progressive increase in surgical interventions in the fields of cardiology and oncology. This situation increasingly involves the need to identify strategies for managing complications that may affect patients in the post-surgical period, during the rehabilitation phase. Among the symptoms most frequently encountered in this context are pain and postural dysfunction, for which a decisive support could derive from the application of Focused Mechano-Acoustic Vibrations (FMAVs) therapy. Methods: In this pilot observational study, 20 patients (12 women and 8 men; average age of 48 years) who underwent cardiac or oncological surgery were observed during the execution of a FMAVs treatment protocol applied in the post-operative period. Patients were evaluated at the beginning and at the end of the protocol through the Numeric Pain Rating Scale (NPRS) and the computerized postural analysis for the calculation of the Postural Biometric Index (PBI), that quantifies postural dysfunctions. All patients were treated with 8 biweekly sessions of FMAVs applied on specific Myofascial Trigger Points (MTrPs). Results: At the end of the protocol, significant reductions of 26.4% for pain detected by NPRS and 17.9% for postural dysfunction detected by PBI were observed. Conclusions: Treatment with FMAVs can determine improvements in pain and postural dysfunction in cardiac and oncological patients subjected to surgery. This preliminary study lays the foundation for further in-depth research on the topic.
Keywords: 
Subject: 
Public Health and Healthcare  -   Physical Therapy, Sports Therapy and Rehabilitation

1. Introduction

Recently, surgical procedures in the oncology and cardiology fields have reached a very high diffusion in the general population; in fact, it is estimated that, to date, approximately 1.5 million cardiac surgery interventions and 9 million oncological surgeries are conducted every year in the world, with values ​​constantly increasing [1,2]. Since cardiac and oncology surgery often involves invasive procedures, a multitude of negative outcomes can frequently be observed, both in the short and long term. In particular, invasive surgical interventions often lead to the onset of depressive states [3,4], pain and reduction of musculoskeletal functionality in patients [5,6,7]. At the musculoskeletal level, this translates into the onset of muscle and joint pain, as well as the appearance of significant postural alterations [8]. Since posture can be defined as the spinal cord reflex manifestation of convergences and facilitation, secondary to cortical expressiveness [9], such changes in the postural alignment of patients may be due to information that are aberrant with respect to that which are naturally at the basis of the construction of the posture. This aberrant information may depend on many factors intrinsic to surgical techniques, which can lead to inevitable iatrogenic lesions of muscle-tendon portions [10], as well as to reconstructive techniques involving the musculoskeletal system and soft tissues [11].
Given the spread of these post-surgical complications, it is essential in the clinical setting to identify strategies to contain the various symptoms that may be encountered.
Among the post-surgical rehabilitation strategies most frequently found in the literature are, for example, physical exercise, breathing exercises or manual therapy, although the efficacy of these treatments is still unclear and is often based on personal experiences and anecdotes [12,13,14].
A new approach that could prove useful in the delicate area of ​​post-surgical management could be represented by non-invasive instrumental therapies, such as Focused Mechano-Acoustic Vibrations (FMAVs). This therapeutic approach is based on the use of focused vibrations determined by variations in air pressure, produced by a turbine, inside plastic cups appropriately positioned on the patient's muscles receiving stimulation [15]. The technique is completely non-invasive and allows, by varying the frequency of the administered vibration, to obtain modulatory effects on basal tone of the stimulated muscles [15,16]. The therapeutic effects of this approach have been observed in many fields, such as geriatrics [17], orthopedics [18], neurology [19], sports medicine [20], urology [21], regenerative medicine [22] and aesthetic medicine [23].
Therefore, in light of the considerations made, in this study we observed the effects possibly induced by treatment with FMAVs in a post-surgical rehabilitation context of cardiac and oncological patients.

2. Materials and Methods

This research is a pilot retrospective analytical observational study carried out at the Gemelli Molise Hospital (Campobasso, Italy), in cooperation with the Ce.Fi.R.R. (Center for Physiotherapy, Rehabilitation and Re-Education) staff from January to June 2023.
All the procedures applied comply with the national safety regulations and the protocol is accessible to anyone who does not highlight specific contraindications during the initial clinical evaluation necessary for all patients who access the hospital. The main major contraindications to access the protocol are pregnancy, epilepsy, electrical implants, infections and tuberculosis. The protocol is not an experimental practice, since it applies the same procedures used at the study facility for all patients who do not present the above-mentioned contraindications. This study was conducted in accordance with the ethical principles of the Declaration of Helsinki. Written informed consent was obtained at enrolment from participants who were willing and able. Furthermore, the Ce.Fi.R.R., as the institution in charge for carrying out the study through part of its staff, owns the ISO 9001:2015 certification for the realization of "Clinical observational studies in the rehabilitation field" (Certificate from the Italian Accreditation Body "Accredia" n. IT15/0304). Due to these considerations and the lack of incontrovertible national legislation regarding the need for the submission of retrospective and/or non-pharmacological observational studies to an ethics committee [24], normal ethics committee clearance was not required [25].
A total of 20 patients (12 women and 8 men; Caucasian ethnicity; average age of 48 years) were observed within the Gemelli Molise Hospital (Campobasso, Italy).
All patients observed had a history of surgery for cardiac or tumor pathology and underwent surgery no more than two months before the start of the treatment protocol. The therapeutic protocol was prescribed by specialist doctors after careful evaluations of the patient's general health status and the possibility and convenience of intervening on his/her post-surgical pain and postural alteration in a minimally invasive way through a complementary approach.
To assess the musculoskeletal health status of patients before (T0) and after (T1) the therapeutic protocol, a routine evaluation of the patients was carried out using 2 diagnostic tools:
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Numeric Pain Rating Scale (NPRS): it is one of the most common tools for measuring the pain subjectively perceived by patients. It is a derivate of the Visual-Analogue Scale (VAS) divided into ten levels, usually distributed equidistant on a 10 cm long strip, which correspond to the level of pain perceived by the patient at the time of the evaluation, where 0 is the total absence of pain and 10 is the maximum level of pain imaginable and/or ever experienced by the patient [26]. This scale is reliable, effective and easy to apply even in the presence of dysfunctions of the general musculoskeletal system [26]. In the case of the present study, patients were asked to express a value from 0 to 10 corresponding to the maximum level of pain perceived at the site of the body which was more painful for them following the surgery;
-
Postural Biometric Index (PBI): this is an index calculated by the proprietary software of the Milletrix 3.0 platform (Diasu Health Technologies, Rome, Italy) on the basis of a stabilometric evaluation carried out using the same device [9]. This index takes into account the parameters of Center of Pressure, Symmetry of Bipodalic Load, Symmetry of Retro-Forefoot Load, Angle of Centers of Pressure, Podalic Angle, Location of Maximum Pressure Point, Symmetry of Support Surface and Center of Gravity Deviation - Center of Pressure [9]. These parameters are then correlated to obtain an index that quantifies the postural state of the patient [9]. The PBI value is considered healthy from 0 to 10 and dysfunctional if >10.
The observed patients were subjected to a protocol consisting of the application of FMAVs 2 times a week for 4 weeks, for a total of 8 sessions lasting approximately 20 minutes each, performed on an outpatient basis. FMAVs therapy was administered using the Vibration Sound System (ViSS) (Vissman Europe S.r.l., Rome, Italy), through a vibrating handpiece guided by the therapist. The handpiece was positioned on multiple body areas in which palpable Myofascial Trigger Points (MTrPs) were located. The presence of MTrPs was assessed by the therapist before each session, through a palpatory examination of the patient's body aimed at identifying the most dysfunctional MTrPs (i.e. more painful to palpation or capable of evoking radiated symptoms). When a potential MTrP was manually detected, the therapist performed a functional evaluation of the range of motion of the district where the MTrP was located; if the range of motion of the suspect district resulted reduced compared to the contralateral one, the palpated MTrP was considered in need of stimulation. Each dysfunctional point was stimulated for a time variable from 3 to 5 minutes until the total 20 minutes of treatment per session were reached. The stimulation frequency was set at 120 Hz.
Given the relatively small size of the observed group of patients, the data collected at time T0 and T1 were processed through the application of a non-parametric Wilcoxon signed-rank test. Data analysis was performed through the Statistics Kingdom open online calculator software (https://www.statskingdom.com, Melbourne, Australia). The observed changes were considered significant for p values ​​< 0.05.

3. Results

At the end of the therapeutic protocol, it was observed that both the NPRS and PBI values have varied in response to the FMAVs treatment.
In particular, the NPRS variable showed a significant reduction (p < 0.01) between times T0 and T1, equal to an average percentage variation of -26.4%, going from a mean value of 6.5 ± 1.6 to 4.7 ± 1.7 (Figure 1).
Similarly, the PBI variable underwent a significant reduction (p < 0.01) between times T0 and T1, equal to a percentage variation of -17.9%, going from an average value of 13.7 ± 3.1 to 11.2 ± 3 (Figure 2).

4. Discussion

The present pilot analytical retrospective observational study has highlighted how the application of a protocol of 8 FMAVs sessions for a period of 4 weeks is able to induce a reduction in pain, detected with the NPRS scale, and postural dysfunction, detected with the PBI calculation, in post-surgical cardiac and oncological patients.
These results appear consistent with what has already been observed in the literature regarding the efficacy of FMAVs in multiple clinical areas of rehabilitation interest [15,16,17,18,19,20,21,22].
Multiple studies in literature have highlighted how vibration therapies are able to reduce musculoskeletal pain, both when applied to the whole body [27,28] and in the case of localized application [29,30]. The mechanisms by which this pain reduction occurs are still a matter of debate. It is believed that a major influence on the analgesic capabilities of vibrations is to be attributed to the stimulation of the Pacinian corpuscles, which can determine the reduction or increase in perceived pain depending on the frequency and amplitude of the vibrations applied locally to the painful areas [31]. It is believed that the pain modulating activity induced by vibrations is primarily attributable to Aβ-fibers activation, as well as to the activation of the limbic system, to the reduced local expression of TRPV1 and calcitonin and to the release of oxytocin [32]. On the contrary, it would seem that the inflammatory aspect of pain is less influenced by vibrational stimulations, which do not seem to be able to induce significant releases of cortisol or opioid neuropeptides in the stimulated tissues [32]. In any case, the vibrational frequency appears to be a more influential parameter than the stimulation intensity in determining the analgesic potential of vibrations, which is best expressed in a range between 100 and 250 Hz [32]. This last consideration appears consistent with what has already been observed regarding the optimal ranges of stimulation using FMAVs, according to which frequencies between 100 and 300 Hz express the greatest potential for modulating pain and muscle tone [15], with frequencies in the range 100-120 Hz appearing to be the most effective in relaxing muscles in a state of increased tension [15]. Considering that the application in this study was performed with a frequency of 120 Hz on various MTrPs identified in the patients, it is possible that the stimulation simultaneously reduced local pain and the state of tension of the treated muscles, inducing a combined effect of reduction of perceived musculoskeletal pain.
With regard to the aspect of postural improvement, more and more evidence can be collected in literature regarding the influence of vibrations, especially focal ones, in improving the parameters of postural stability and efficiency of various types of subjects, both in the pathological [33,34] and sports fields [35,36]. It is assumed that the modulation activity of the muscular properties attributable to the FMAVs can determine the improvement of parameters such as strength, resistance, coordination and stability, with positive effects on the postural attitude of the treated subjects. This also appears consistent with what has been experienced in terms of efficacy of FMAVs in the treatment of musculoskeletal and neuromuscular problems, according to a bio-physico-metric approach aimed at improving the postural quality of patients whose pathologies could be linked to the presence of MTrPs [14,37].
Howsoever, it should be highlighted that the average value of postural dysfunction detected through the PBI test at the end of the treatment protocol, although significantly improved, was still slightly higher than the maximum acceptable value of 10 [9]. Taking into account the positive trend of the PBI value detected in our study, this observation indicates that a FMAVs protocol could probably require more time or more frequent sessions to normalize the posture of post-surgical patients, while inducing a reduction in pain to levels below appreciable algesia more rapidly.
Although the results of this study appear encouraging, some limitations of this research must be highlighted. First of all, the study sample is relatively small and not sufficiently homogeneous. This is due to the observational nature of the study, which did not allow for the implementation of strict sample selection procedures, being able to consider only patients who had a similar, but not identical, clinical history and who had undertaken the same treatment protocol in the post-surgical period. Furthermore, for the same reasons, it was not possible to effectively configure a follow-up period or an adequate control group. Nonetheless, the observational setting of the study allowed for the evaluation of the effects of FMAVs directly in the operational field, in a more real clinical context, configuring this research as a pilot for possible experimental studies on the same topic, which could include a larger sample, a control group and a follow-up period, in order to confirm or deny the positive effects of FMAVs observed in this study.

5. Conclusions

This pilot observational study demonstrates how the application of a 4-week FMAVs protocol in post-surgical patients of the cardiac or oncological type is able to produce a significant improvement in pain and postural dysfunction that occur after the surgery. Since the identification of new therapeutic strategies capable of speeding up the recovery of patients of this type could improve the quality of life of the patients themselves and optimize health resources by making the terms of post-surgical hospitalization more efficient, it could be interesting to investigate more extensively on FMAVs in this therapeutic-rehabilitative context.

Author Contributions

Conceptualization, G.B. and M.P.; methodology, G.B.; software, A.D.I.; validation, R.P.; formal analysis, M.P.; investigation, G.B. and A.M.; resources, M.P.; data curation, A.D.I.; writing—original draft preparation, G.B. and L.P.; writing—review and editing, L.P., G.L.M. and P.E.G.; visualization, C.M.; supervision, G.L.M. and P.E.G.; project administration, G.B.; funding acquisition, M.P. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

Ethical review and approval were waived for this study due to the fact that the protocol is not an experimental practice, since it applies the same procedures used for all patients who do not present the aforementioned contraindications. This study was conducted in accordance with the ethical principles of the Declaration of Helsinki. Written informed consent was obtained at enrolment from participants who were willing and able. Furthermore, the Ce.Fi.R.R., as the institution in charge for carrying out the study through part of its staff, owns the ISO 9001:2015 certification for the realization of "Clinical observational studies in the rehabilitation field" (Certificate from the Italian Accreditation Body "Accredia" n. IT15/0304). Due to these considerations and the lack of incontrovertible national legislation regarding the need for the submission of retrospective and/or non-pharmacological observational studies to an ethics committee, normal ethics committee clearance was not required.

Informed Consent Statement

Written informed consent was obtained at enrolment from participants who were willing and able.

Data Availability Statement

The data presented in this study, due to the preservation of the privacy of interested parties, could be made available upon motivated and reasonable private request to the corresponding author.

Conflicts of Interest

The authors declare no conflicts of interest.

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Figure 1. Box plots of NPRS values ​​at times T0 and T1.
Figure 1. Box plots of NPRS values ​​at times T0 and T1.
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Figure 2. Box plots of PBI values ​​at times T0 and T1.
Figure 2. Box plots of PBI values ​​at times T0 and T1.
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Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
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