Version 1
: Received: 22 October 2024 / Approved: 24 October 2024 / Online: 24 October 2024 (16:03:51 CEST)
How to cite:
Niazi, S. K.; Magoola, M. MicroRNA Nobel Prize: A Timely Recognition, and a High Anticipation—A Detailed Analysis to Assist. Preprints2024, 2024101972. https://doi.org/10.20944/preprints202410.1972.v1
Niazi, S. K.; Magoola, M. MicroRNA Nobel Prize: A Timely Recognition, and a High Anticipation—A Detailed Analysis to Assist. Preprints 2024, 2024101972. https://doi.org/10.20944/preprints202410.1972.v1
Niazi, S. K.; Magoola, M. MicroRNA Nobel Prize: A Timely Recognition, and a High Anticipation—A Detailed Analysis to Assist. Preprints2024, 2024101972. https://doi.org/10.20944/preprints202410.1972.v1
APA Style
Niazi, S. K., & Magoola, M. (2024). MicroRNA Nobel Prize: A Timely Recognition, and a High Anticipation—A Detailed Analysis to Assist. Preprints. https://doi.org/10.20944/preprints202410.1972.v1
Chicago/Turabian Style
Niazi, S. K. and Matthias Magoola. 2024 "MicroRNA Nobel Prize: A Timely Recognition, and a High Anticipation—A Detailed Analysis to Assist" Preprints. https://doi.org/10.20944/preprints202410.1972.v1
Abstract
microRNAS (miRNAs) maintain cellular homeostasis by blocking mRNAs through binding with t-RNA to fine-tune the expression of genes across numerous biological pathways. The 2024 Nobel Prize in Medicine and Physiology for the discovery of miRNA was long overdue and now we anticipate a deluge of research work involving miRNA to repeat the history with other RNA prizes. While miRNA therapies include several complex diseases, the realization that miRNA regulates genes, its role in addressing therapies of hundreds of diseases is expected but with advancement in drug discovery tools, we anticipate faster entry of new drug entities; to promote this, we provide details of the current science, logic, intellectual property, formulations and regulatory process with anticipation that now many more researchers will deliver novel therapies based on the discussion and advice provided in this paper.
Keywords
microRNA; RNA; Nobel Prize; mRNA inhibition; therapies; Ex vivo vs In vivo; Regulatory; Intellectual property; off-target; development and testing
Subject
Medicine and Pharmacology, Clinical Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
