Version 1
: Received: 25 October 2024 / Approved: 25 October 2024 / Online: 25 October 2024 (15:07:38 CEST)
How to cite:
Quodling, N.; Groves, S.; Hoffman, N.; Carrick, F. R.; Jemni, M. Trauma-based Sexually Dimorphic Changes in the Connectome and its Association with Central Sensitisation Syndromes - A Systematic Review. Preprints2024, 2024102051. https://doi.org/10.20944/preprints202410.2051.v1
Quodling, N.; Groves, S.; Hoffman, N.; Carrick, F. R.; Jemni, M. Trauma-based Sexually Dimorphic Changes in the Connectome and its Association with Central Sensitisation Syndromes - A Systematic Review. Preprints 2024, 2024102051. https://doi.org/10.20944/preprints202410.2051.v1
Quodling, N.; Groves, S.; Hoffman, N.; Carrick, F. R.; Jemni, M. Trauma-based Sexually Dimorphic Changes in the Connectome and its Association with Central Sensitisation Syndromes - A Systematic Review. Preprints2024, 2024102051. https://doi.org/10.20944/preprints202410.2051.v1
APA Style
Quodling, N., Groves, S., Hoffman, N., Carrick, F. R., & Jemni, M. (2024). Trauma-based Sexually Dimorphic Changes in the Connectome and its Association with Central Sensitisation Syndromes - A Systematic Review. Preprints. https://doi.org/10.20944/preprints202410.2051.v1
Chicago/Turabian Style
Quodling, N., Frederick Robert Carrick and Monem Jemni. 2024 "Trauma-based Sexually Dimorphic Changes in the Connectome and its Association with Central Sensitisation Syndromes - A Systematic Review" Preprints. https://doi.org/10.20944/preprints202410.2051.v1
Abstract
Background/Objectives: Chronic pain syndromes pose a significant global health challenge to patients and physicians with a complex relationship of biological and psychosocial factors that are only partly understood. Emerging research suggests an association between prenatal and childhood adversity and the development of somatic syndromes, particularly in females. This study aims to explore the relationship between sexual dimorphic epigenetic changes in the connectome and prenatal and early life adversity (ELA). Methods: A review of existing literature was conducted, examining studies utilising MRI to identify critical periods of environmental influence on neural phenotypes. Results: The findings indicate a significant association between prenatal and childhood adversity and the emergence of central sensitisation syndromes, particularly among females. Notably, alterations in grey matter volume and neural connectivity patterns were observed, suggesting that early adverse experiences can influence pain signalling mechanisms. Conclusions: Understanding the role of sex differences in brain circuitry is crucial for developing personalised pain management strategies. This study highlights the importance of considering both biological and psychosocial factors in addressing chronic pain, as interventions based predominantly on male subjects may be less effective for females. Further research is warranted to explore these differences and refine therapeutic approaches.
Keywords
Chronic pain syndromes; Fibromyalgia; Neuropathic pain; Prenatal and early life adversity
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
