Version 1
: Received: 24 October 2024 / Approved: 25 October 2024 / Online: 28 October 2024 (09:35:54 CET)
How to cite:
Placidi, M.; Casoli, G.; Tatone, C.; Di Emidio, G.; Bevilacqua, A. Myo-Inositol and Its Derivatives: Their Role in the Challenges of Infertility. Preprints2024, 2024102057. https://doi.org/10.20944/preprints202410.2057.v1
Placidi, M.; Casoli, G.; Tatone, C.; Di Emidio, G.; Bevilacqua, A. Myo-Inositol and Its Derivatives: Their Role in the Challenges of Infertility. Preprints 2024, 2024102057. https://doi.org/10.20944/preprints202410.2057.v1
Placidi, M.; Casoli, G.; Tatone, C.; Di Emidio, G.; Bevilacqua, A. Myo-Inositol and Its Derivatives: Their Role in the Challenges of Infertility. Preprints2024, 2024102057. https://doi.org/10.20944/preprints202410.2057.v1
APA Style
Placidi, M., Casoli, G., Tatone, C., Di Emidio, G., & Bevilacqua, A. (2024). Myo-Inositol and Its Derivatives: Their Role in the Challenges of Infertility. Preprints. https://doi.org/10.20944/preprints202410.2057.v1
Chicago/Turabian Style
Placidi, M., Giovanna Di Emidio and Arturo Bevilacqua. 2024 "Myo-Inositol and Its Derivatives: Their Role in the Challenges of Infertility" Preprints. https://doi.org/10.20944/preprints202410.2057.v1
Abstract
Myo-inositol (MYO) and D-chiro-inositol (DCI) are the two most significant isomeric forms of inositol, playing a critical role in intracellular signaling. MYO is the most abundant form of inositol in nature; DCI is produced from MYO through epimerization by an insulin-dependent enzyme. Recently, it has been demonstrated that inositols may influence oocyte maturation, improve intracellular Ca2+ oscillation in the oocytes and have been proposed as potential interventions for restoring spontaneous ovulation. MYO concentration in human follicular fluid is considered a bioindicator of oocyte quality. In the ovary, DCI modulates the activity of aromatase thus regulating androgen synthesis. Under physiological conditions, MYO/DCI ratio is maintained at 40:1 in the plasma. In women with PCOS, MYO/DCI ratio lowers to 0:2:1, contributing to elevated androgen production. By regulating FSH signaling, MYO administration increases the number of high-quality embryos available for transfer in poor responder patients. Finally, by acting downstream to insulin signaling inositol administration during pregnancy may represent a novel strategy for counteracting gestational diabetes. These findings show that diet supplementation with inositols may be a promising strategy to address female infertility and sustain healthy pregnancy.
Biology and Life Sciences, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
