Beyond Fluoride: Exploring Silicon's Potential for Dental Repair and Caries Prevention

Andressa Feitosa Bezerra Oliveira; Biane Maria Melo Costa; Anderson Gomes Forte; Elizabeth Barreto Galvão Sousa; Vitória Régia Rolim Nunes; Arthur Felipe Brito Andrade; Juliellen Luiz Cunha; Nayanna Lana Soares Fernandes; Ana Maria Barros Chaves Pereira; Fabiano Vieira Vilhena; Paulo Henrique Perlatti D’Alpino; Fábio Correia Sampaio

doi:10.20944/preprints202410.2237.v1

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preprints.org > medicine and pharmacology > dentistry and oral surgery > doi: 10.20944/preprints202410.2237.v1 (registering DOI)

Preprint Article Version 1 This version is not peer-reviewed

Beyond Fluoride: Exploring Silicon's Potential for Dental Repair and Caries Prevention

Andressa Feitosa Bezerra Oliveira

^* ,

Biane Maria Melo Costa

Anderson Gomes Forte

Elizabeth Barreto Galvão Sousa

Vitória Régia Rolim Nunes

Arthur Felipe Brito Andrade

Juliellen Luiz Cunha

Nayanna Lana Soares Fernandes

Ana Maria Barros Chaves Pereira

Fabiano Vieira Vilhena

Paulo Henrique Perlatti D’Alpino

Fábio Correia Sampaio

Version 1 : Received: 28 October 2024 / Approved: 29 October 2024 / Online: 30 October 2024 (05:28:05 CET)

How to cite: Oliveira, A. F. B.; Costa, B. M. M.; Forte, A. G.; Sousa, E. B. G.; Nunes, V. R. R.; Andrade, A. F. B.; Cunha, J. L.; Fernandes, N. L. S.; Pereira, A. M. B. C.; Vilhena, F. V.; D’Alpino, P. H. P.; Sampaio, F. C. Beyond Fluoride: Exploring Silicon's Potential for Dental Repair and Caries Prevention. Preprints 2024, 2024102237. https://doi.org/10.20944/preprints202410.2237.v1 Oliveira, A. F. B.; Costa, B. M. M.; Forte, A. G.; Sousa, E. B. G.; Nunes, V. R. R.; Andrade, A. F. B.; Cunha, J. L.; Fernandes, N. L. S.; Pereira, A. M. B. C.; Vilhena, F. V.; D’Alpino, P. H. P.; Sampaio, F. C. Beyond Fluoride: Exploring Silicon's Potential for Dental Repair and Caries Prevention. Preprints 2024, 2024102237. https://doi.org/10.20944/preprints202410.2237.v1

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MDPI and ACS Style

Oliveira, A. F. B.; Costa, B. M. M.; Forte, A. G.; Sousa, E. B. G.; Nunes, V. R. R.; Andrade, A. F. B.; Cunha, J. L.; Fernandes, N. L. S.; Pereira, A. M. B. C.; Vilhena, F. V.; D’Alpino, P. H. P.; Sampaio, F. C. Beyond Fluoride: Exploring Silicon's Potential for Dental Repair and Caries Prevention. Preprints 2024, 2024102237. https://doi.org/10.20944/preprints202410.2237.v1

APA Style

Oliveira, A. F. B., Costa, B. M. M., Forte, A. G., Sousa, E. B. G., Nunes, V. R. R., Andrade, A. F. B., Cunha, J. L., Fernandes, N. L. S., Pereira, A. M. B. C., Vilhena, F. V., D’Alpino, P. H. P., & Sampaio, F. C. (2024). Beyond Fluoride: Exploring Silicon's Potential for Dental Repair and Caries Prevention. Preprints. https://doi.org/10.20944/preprints202410.2237.v1

Chicago/Turabian Style

Oliveira, A. F. B., Paulo Henrique Perlatti D’Alpino and Fábio Correia Sampaio. 2024 "Beyond Fluoride: Exploring Silicon's Potential for Dental Repair and Caries Prevention" Preprints. https://doi.org/10.20944/preprints202410.2237.v1

Abstract

This in vitro study evaluated the protective effect of a Si-containing toothpaste associated with different fluoride concentrations by reducing the depth of demineralized lesions in dentin after cariogenic pH cycling. Methods: Sixty bovine dentin blocks (4x4x2mm) were randomly assigned into five groups (n = 12/group): RGS1 (Si-toothpaste with 1450 ppm F), RGS2 (Si-toothpaste with 1100 ppm F), RGS3 (fluoride-free Si-toothpaste), negative control-NC (fluoride-free toothpaste), and positive control-PC (1450 ppm F toothpaste). The specimens underwent a three-day pH cycling model simulating the oral environment with twice-daily brushing. Mineral loss (ΔF) and lesion depth (ΔFmax) were assessed using quantitative light-induced fluorescence (QLF), and scanning electron microscopy (SEM) provided morphological analysis. Elemental analyses were determined with an energy-dispersive X-ray spectrometer (EDS). ANOVA/Tukey's test were used for data analysis (α = 5%). Results: The groups treated with fluoride silicon-toothpastes (RGS1, RGS2) significantly reduced the mineral loss and lesion depth compared to the PC group. The NC group exhibited the greatest mineral loss and lesion depth. SEM images revealed occluded superficial dentin tubules and a protective mineral layer in groups treated with Si-toothpaste, whereas no deposition (NC group) or a limited mineral deposition (PC group) was observed in the control groups. EDS confirmed Si in the toothpaste formulations. Conclusions: Findings suggest that Si-toothpastes favored protection against dentin demineralization even at a lower concentration or free of fluoride, with dentin tubule occlusion, thus consisting of a promising oral care product over traditional fluoride toothpastes.

Keywords

Dental caries; Biomimetics; Fluoride; Silicon; Remineralization; Dentin

Subject

Medicine and Pharmacology, Dentistry and Oral Surgery

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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