Drug Repurposing for Cancer Treatment: A Comprehensive Review

Abdulaziz H. Al Khzem; Mohamed Sayed Gomaa; Mansour Alturki; Nada Tawfeeq; Mohammad Sarafroz; Shareefa Alonaizi; Alhassan Al Faran; Laela Alrumaihi; Fatima Alansari; Abdullah Alghamdi

doi:10.20944/preprints202410.2321.v1

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preprints.org > chemistry and materials science > medicinal chemistry > doi: 10.20944/preprints202410.2321.v1 (registering DOI)

Preprint Review Version 1 This version is not peer-reviewed

Drug Repurposing for Cancer Treatment: A Comprehensive Review

Abdulaziz H. Al Khzem

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Version 1 : Received: 29 October 2024 / Approved: 29 October 2024 / Online: 30 October 2024 (05:32:33 CET)

How to cite: Al Khzem, A. H.; Gomaa, M. S.; Alturki, M.; Tawfeeq, N.; Sarafroz, M.; Alonaizi, S.; Al Faran, A.; Alrumaihi, L.; Alansari, F.; Alghamdi, A. Drug Repurposing for Cancer Treatment: A Comprehensive Review. Preprints 2024, 2024102321. https://doi.org/10.20944/preprints202410.2321.v1 Al Khzem, A. H.; Gomaa, M. S.; Alturki, M.; Tawfeeq, N.; Sarafroz, M.; Alonaizi, S.; Al Faran, A.; Alrumaihi, L.; Alansari, F.; Alghamdi, A. Drug Repurposing for Cancer Treatment: A Comprehensive Review. Preprints 2024, 2024102321. https://doi.org/10.20944/preprints202410.2321.v1

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MDPI and ACS Style

Al Khzem, A. H.; Gomaa, M. S.; Alturki, M.; Tawfeeq, N.; Sarafroz, M.; Alonaizi, S.; Al Faran, A.; Alrumaihi, L.; Alansari, F.; Alghamdi, A. Drug Repurposing for Cancer Treatment: A Comprehensive Review. Preprints 2024, 2024102321. https://doi.org/10.20944/preprints202410.2321.v1

APA Style

Al Khzem, A. H., Gomaa, M. S., Alturki, M., Tawfeeq, N., Sarafroz, M., Alonaizi, S., Al Faran, A., Alrumaihi, L., Alansari, F., & Alghamdi, A. (2024). Drug Repurposing for Cancer Treatment: A Comprehensive Review. Preprints. https://doi.org/10.20944/preprints202410.2321.v1

Chicago/Turabian Style

Al Khzem, A. H., Fatima Alansari and Abdullah Alghamdi. 2024 "Drug Repurposing for Cancer Treatment: A Comprehensive Review" Preprints. https://doi.org/10.20944/preprints202410.2321.v1

Abstract

Cancer ranks among the primary contributors to global mortality. In 2022, the global incidence of new cancer cases reached about 20 million, while the number of cancer-related fatalities reached 9.7 million. Exclusively in Saudi Arabia, there are 13,399 deaths caused by cancer and 28,113 newly diagnosed cases of cancer. Drug repurposing is a drug discovery strategy that gained special attention and implementation to enhance the process of drug development due to its time and money saving effect. It involves repositioning existing medications to new clinical applications. Cancer treatment is one of the most therapeutic areas where drug repurposing has shown prominent impact. This review presents a compilation of medications that have been repurposed for the treatment of various types of cancers. It describes the initial therapeutic and pharmacological classes of the repurposed drugs and their new applications and mechanism of action in cancer treatment. The review reports on drugs from various pharmacological classes that have been successfully repurposed for cancer treatment including approved ones and those in clinical trials and preclinical development. It stratifies drugs based on their anticancer repurpose as multi-type, type-specific, and mechanism directed and according to their pharmacological classes. The review also reflects on the future potential that drug repurposing has in the clinical development of novel anticancer therapies.

Keywords

Repurposing; Anticancer; Drug Discovery; Therapeutic Classes; Translational Research; Drug Targets

Subject

Chemistry and Materials Science, Medicinal Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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