Genetic Blueprints in Lung Cancer: Foundations for Targeted Therapies

How to cite: Dan, A.; Burtavel, L.-M.; Coman, M.-C.; Focsa, I. O.; Duta-Ion, S.; Juganaru, I.-R.; Zaruha, A.-G.; Strugari, I.-M.; Hotinceanu, I. A.; Codreanu, P.-C.; Bohiltea, L.-C.; Rădoi, V. E. Genetic Blueprints in Lung Cancer: Foundations for Targeted Therapies. Preprints 2024, 2024102445. https://doi.org/10.20944/preprints202410.2445.v1 Dan, A.; Burtavel, L.-M.; Coman, M.-C.; Focsa, I. O.; Duta-Ion, S.; Juganaru, I.-R.; Zaruha, A.-G.; Strugari, I.-M.; Hotinceanu, I. A.; Codreanu, P.-C.; Bohiltea, L.-C.; Rădoi, V. E. Genetic Blueprints in Lung Cancer: Foundations for Targeted Therapies. Preprints 2024, 2024102445. https://doi.org/10.20944/preprints202410.2445.v1

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MDPI and ACS Style

Dan, A.; Burtavel, L.-M.; Coman, M.-C.; Focsa, I. O.; Duta-Ion, S.; Juganaru, I.-R.; Zaruha, A.-G.; Strugari, I.-M.; Hotinceanu, I. A.; Codreanu, P.-C.; Bohiltea, L.-C.; Rădoi, V. E. Genetic Blueprints in Lung Cancer: Foundations for Targeted Therapies. Preprints 2024, 2024102445. https://doi.org/10.20944/preprints202410.2445.v1

APA Style

Dan, A., Burtavel, L. M., Coman, M. C., Focsa, I. O., Duta-Ion, S., Juganaru, I. R., Zaruha, A. G., Strugari, I. M., Hotinceanu, I. A., Codreanu, P. C., Bohiltea, L. C., & Rădoi, V. E. (2024). Genetic Blueprints in Lung Cancer: Foundations for Targeted Therapies. Preprints. https://doi.org/10.20944/preprints202410.2445.v1

Chicago/Turabian Style

Dan, A., Laurentiu-Camil Bohiltea and Viorica Elena Rădoi. 2024 "Genetic Blueprints in Lung Cancer: Foundations for Targeted Therapies" Preprints. https://doi.org/10.20944/preprints202410.2445.v1

Abstract

This article provides a comprehensive overview of lung cancer from a genetic perspective, emphasizing the molecular pathways involved in its pathogenesis. This review presents the genetic syndromes and key genomic variations, including alterations and instabilities, that contribute to tumor development and progression. Furthermore, advancements in genomic testing, such as liquid biopsy, are explored, highlighting their utility in early diagnosis, prognostic evaluation, and personalized treatment strategies. The role of biomarkers in informing therapeutic decisions and optimizing patient outcomes is also examined, offering insights into their potential to refine clinical interventions. This review aims to enrich the understanding of the genetic landscape of lung cancer, providing insights that may lead to improved diagnostic and therapeutic approaches.

Keywords

lung cancer; NSCLC; SCLC; genetics; pathways; alterations; biomarkers; diagnosis; therapies; personalized medicine

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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