Preprint Review Version 1 This version is not peer-reviewed

Genetic Blueprints in Lung Cancer: Foundations for Targeted Therapies

Version 1 : Received: 30 October 2024 / Approved: 30 October 2024 / Online: 30 October 2024 (14:34:52 CET)

How to cite: Dan, A.; Burtavel, L.-M.; Coman, M.-C.; Focsa, I. O.; Duta-Ion, S.; Juganaru, I.-R.; Zaruha, A.-G.; Strugari, I.-M.; Hotinceanu, I. A.; Codreanu, P.-C.; Bohiltea, L.-C.; Rădoi, V. E. Genetic Blueprints in Lung Cancer: Foundations for Targeted Therapies. Preprints 2024, 2024102445. https://doi.org/10.20944/preprints202410.2445.v1 Dan, A.; Burtavel, L.-M.; Coman, M.-C.; Focsa, I. O.; Duta-Ion, S.; Juganaru, I.-R.; Zaruha, A.-G.; Strugari, I.-M.; Hotinceanu, I. A.; Codreanu, P.-C.; Bohiltea, L.-C.; Rădoi, V. E. Genetic Blueprints in Lung Cancer: Foundations for Targeted Therapies. Preprints 2024, 2024102445. https://doi.org/10.20944/preprints202410.2445.v1

Abstract

This article provides a comprehensive overview of lung cancer from a genetic perspective, emphasizing the molecular pathways involved in its pathogenesis. This review presents the genetic syndromes and key genomic variations, including alterations and instabilities, that contribute to tumor development and progression. Furthermore, advancements in genomic testing, such as liquid biopsy, are explored, highlighting their utility in early diagnosis, prognostic evaluation, and personalized treatment strategies. The role of biomarkers in informing therapeutic decisions and optimizing patient outcomes is also examined, offering insights into their potential to refine clinical interventions. This review aims to enrich the understanding of the genetic landscape of lung cancer, providing insights that may lead to improved diagnostic and therapeutic approaches.

Keywords

lung cancer; NSCLC; SCLC; genetics; pathways; alterations; biomarkers; diagnosis; therapies; personalized medicine

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.