Version 1
: Received: 30 October 2024 / Approved: 30 October 2024 / Online: 31 October 2024 (09:57:55 CET)
How to cite:
Rolle, V.; Chaveeva, P.; Diaz-Navarro, A.; Fernández-Buhigas, I.; Cuenca-Gómez, D.; Tilkova, T.; Santacruz, B.; Pérez, T.; Gil, M. D. M. Continuous Risk Assessment of Late and Term Preeclampsia Throughout Pregnancy: A Retrospective Cohort Study. Preprints2024, 2024102488. https://doi.org/10.20944/preprints202410.2488.v1
Rolle, V.; Chaveeva, P.; Diaz-Navarro, A.; Fernández-Buhigas, I.; Cuenca-Gómez, D.; Tilkova, T.; Santacruz, B.; Pérez, T.; Gil, M. D. M. Continuous Risk Assessment of Late and Term Preeclampsia Throughout Pregnancy: A Retrospective Cohort Study. Preprints 2024, 2024102488. https://doi.org/10.20944/preprints202410.2488.v1
Rolle, V.; Chaveeva, P.; Diaz-Navarro, A.; Fernández-Buhigas, I.; Cuenca-Gómez, D.; Tilkova, T.; Santacruz, B.; Pérez, T.; Gil, M. D. M. Continuous Risk Assessment of Late and Term Preeclampsia Throughout Pregnancy: A Retrospective Cohort Study. Preprints2024, 2024102488. https://doi.org/10.20944/preprints202410.2488.v1
APA Style
Rolle, V., Chaveeva, P., Diaz-Navarro, A., Fernández-Buhigas, I., Cuenca-Gómez, D., Tilkova, T., Santacruz, B., Pérez, T., & Gil, M. D. M. (2024). Continuous Risk Assessment of Late and Term Preeclampsia Throughout Pregnancy: A Retrospective Cohort Study. Preprints. https://doi.org/10.20944/preprints202410.2488.v1
Chicago/Turabian Style
Rolle, V., Teresa Pérez and Maria del Mar Gil. 2024 "Continuous Risk Assessment of Late and Term Preeclampsia Throughout Pregnancy: A Retrospective Cohort Study" Preprints. https://doi.org/10.20944/preprints202410.2488.v1
Abstract
Background and Objectives: To evaluate the diagnostic accuracy of widely available biomarkers longitudinally measured throughout pregnancy to predict all and term (delivery at ≥ 37 weeks) preeclampsia (PE). Materials and Methods: This is a retrospective study performed at Hospital Universitario de Torrejón (Madrid, Spain) and Shterev Hospital (Sofia, Bulgaria) between August 2017 and December 2022. All pregnant women with singleton pregnancies and non-malformed live fetuses attending their routine ultrasound examination and first-trimester screening for preterm PE at 11+0 to 13+6 weeks' gestation at the participating centers were invited to participate in a larger study for the prediction of pregnancy complications. The dataset was divided into two subsets to develop and validate a joint model of time-to-event outcome and longitudinal data, and to evaluate how the area under the receiving operating characteristic curve (AUROC) evolved with time. Results: 4056 pregnancies were included in the training set (59 all PE, 40 term PE) and 944 in the validation set (23 all PE, 20 term PE). For the joint model and all PE, the AUROC was 0.84 (95% CI 0.73 to 0.94) and the detection rate (DR) for a 10% screening positive rate (SPR) was 56.5 (95% CI 34.5 to 76.8). For term PE, AUROC was 0.80 (95% CI 0.69 to 0.91), and DR for a 10% SPR was 55.0 (95% CI 31.5 to 76.9). The AUROC using only information from the first trimester was 0.50 (95% CI 0.37 to 0.64) and it increased up to 0.84 (0.73 to 0.94) when using all information available. Conclusions: Routinely measuring MAP and UtA-PI throughout pregnancy may improve the predictive prediction power for all and term-PE.
Medicine and Pharmacology, Obstetrics and Gynaecology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
