Correction of Multispectral Singlet Oxygen Luminescent Dosimetry (MSOLD) for Tissue Optical Properties in Photofrin-Mediated Photodynamic Therapy

Weibing Yang; Madelyn Johnson; Baozhu Lu; Dennis Sourvanos; Hongjing Sun; Andreea Dimofte; Vikas Vikas; Theresa M. Busch; Robert H. Hadfield; Brian C. Wilson; Timothy C. Zhu

doi:10.20944/preprints202411.0067.v1

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preprints.org > biology and life sciences > biology and biotechnology > doi: 10.20944/preprints202411.0067.v1

Preprint Communication Version 1 This version is not peer-reviewed

Correction of Multispectral Singlet Oxygen Luminescent Dosimetry (MSOLD) for Tissue Optical Properties in Photofrin-Mediated Photodynamic Therapy

^* ,

Version 1 : Received: 31 October 2024 / Approved: 1 November 2024 / Online: 1 November 2024 (18:39:18 CET)

How to cite: Yang, W.; Johnson, M.; Lu, B.; Sourvanos, D.; Sun, H.; Dimofte, A.; Vikas, V.; Busch, T. M.; Hadfield, R. H.; Wilson, B. C.; Zhu, T. C. Correction of Multispectral Singlet Oxygen Luminescent Dosimetry (MSOLD) for Tissue Optical Properties in Photofrin-Mediated Photodynamic Therapy. Preprints 2024, 2024110067. https://doi.org/10.20944/preprints202411.0067.v1 Yang, W.; Johnson, M.; Lu, B.; Sourvanos, D.; Sun, H.; Dimofte, A.; Vikas, V.; Busch, T. M.; Hadfield, R. H.; Wilson, B. C.; Zhu, T. C. Correction of Multispectral Singlet Oxygen Luminescent Dosimetry (MSOLD) for Tissue Optical Properties in Photofrin-Mediated Photodynamic Therapy. Preprints 2024, 2024110067. https://doi.org/10.20944/preprints202411.0067.v1

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MDPI and ACS Style

Yang, W.; Johnson, M.; Lu, B.; Sourvanos, D.; Sun, H.; Dimofte, A.; Vikas, V.; Busch, T. M.; Hadfield, R. H.; Wilson, B. C.; Zhu, T. C. Correction of Multispectral Singlet Oxygen Luminescent Dosimetry (MSOLD) for Tissue Optical Properties in Photofrin-Mediated Photodynamic Therapy. Preprints 2024, 2024110067. https://doi.org/10.20944/preprints202411.0067.v1

APA Style

Yang, W., Johnson, M., Lu, B., Sourvanos, D., Sun, H., Dimofte, A., Vikas, V., Busch, T. M., Hadfield, R. H., Wilson, B. C., & Zhu, T. C. (2024). Correction of Multispectral Singlet Oxygen Luminescent Dosimetry (MSOLD) for Tissue Optical Properties in Photofrin-Mediated Photodynamic Therapy. Preprints. https://doi.org/10.20944/preprints202411.0067.v1

Chicago/Turabian Style

Yang, W., Brian C. Wilson and Timothy C. Zhu. 2024 "Correction of Multispectral Singlet Oxygen Luminescent Dosimetry (MSOLD) for Tissue Optical Properties in Photofrin-Mediated Photodynamic Therapy" Preprints. https://doi.org/10.20944/preprints202411.0067.v1

Abstract

Direct detection of singlet-state oxygen (1O2) constitutes the holy grail dosimetric method for type-II photodynamic therapy (PDT), a goal that can be quantified using multispectral singlet oxygen near-infrared luminescence dosimetry (MSOLD). The optical properties of tissues, specifically their scattering and absorption coefficients, play a crucial role in determining how the treatment and luminescence light are attenuated. Variations in these properties can significantly impact the spatial distribution of the treatment light and hence the generation of singlet oxygen, and the detection of singlet oxygen luminescence signals. In this study, we investigated the impact of varying optical properties on the detection of 1O2 luminescence signals during Photofrin-mediated PDT in tissue-mimicking phantoms. For comparison, we also conducted Monte Carlo (MC) simulations under the same conditions. The experimental and simulations are substantially equivalent. This study advances understanding of MSOLD dosimetry during PDT.

Keywords

photodynamic therapy (PDT); singlet oxygen luminescence; tissue optical properties

Subject

Biology and Life Sciences, Biology and Biotechnology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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