Review
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Exploring Foundational Experiments in GlycoRNA
Version 1
: Received: 1 November 2024 / Approved: 1 November 2024 / Online: 1 November 2024 (18:37:11 CET)
How to cite: Parsons, J. V. Exploring Foundational Experiments in GlycoRNA. Preprints 2024, 2024110096. https://doi.org/10.20944/preprints202411.0096.v1 Parsons, J. V. Exploring Foundational Experiments in GlycoRNA. Preprints 2024, 2024110096. https://doi.org/10.20944/preprints202411.0096.v1
Abstract
In traditional models of molecular and cellular biology, RNA has been limited to primarily intracellular function in mammalian cells, and has only been subject to chemically simple post-transcriptional modifications. Recent advances have identified an isoform of RNA that challenges this model in two major ways: by expanding its domain to the mammalian cell surface, and identifying it as a target for glycosylation. This isoform, termed glycoRNA, has elevated the nucleic acid from an enzymatic biopolymer to a potential cell signaling molecule with implications for human disease phenotypes. In this review, we summarize the key features of glycoRNA and explore early studies as to its cellular role. We also collate information on glycoRNA-expressing cell lines and high-confidence glycosylated transcripts, providing several resources to assist future studies. Finally, we highlight the important challenges and next steps to characterize this novel glycoconjugate.
Keywords
glycoRNA; RNA; glycosylation; cell surface; plasma membrane; autoimmunity
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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