Preprint Review Version 1 This version is not peer-reviewed

Endocrine Hormones and Their Impact on Pubertal Gynecomastia

Version 1 : Received: 1 November 2024 / Approved: 1 November 2024 / Online: 5 November 2024 (04:44:48 CET)

How to cite: Shi, Z.; Xin, M. Endocrine Hormones and Their Impact on Pubertal Gynecomastia. Preprints 2024, 2024110119. https://doi.org/10.20944/preprints202411.0119.v1 Shi, Z.; Xin, M. Endocrine Hormones and Their Impact on Pubertal Gynecomastia. Preprints 2024, 2024110119. https://doi.org/10.20944/preprints202411.0119.v1

Abstract

Pubertal gynecomastia (PG) refers to the abnormal development and hyperplasia of unilateral or bilateral breast tissue in adolescent males, a common condition with a prevalence of up to 50% among appropriately aged adolescents, and an increasing incidence trend over the years. The etiology of PG is multifactorial, including physiological, pharmacological, and pathological causes. Endocrine hormones play a crucial role in the pathogenesis of PG across different etiologies. This review provides a detailed discussion on the effects of various endocrine hormones, including FSH, LH, T, E2, PRL, GH, and thyroid hormones, on pubertal gynecomastia in adolescent males, aiming to offer valuable insights for clinical diagnosis and treatment.

Keywords

puberty; gynecomastia; sex hormones; endocrinology; adolescence

Subject

Medicine and Pharmacology, Endocrinology and Metabolism

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